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N194

NS-398

Name: NS-398
Brand: SIGMA

≥98% (HPLC), solid

别名:

N-[2-(环己氧基)-4-硝基苯基]甲磺酰胺

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关于此项目

经验公式（希尔记法）:

C₁₃H₁₈N₂O₅S

化学文摘社编号:

123653-11-2

分子量:

314.36

NACRES:

NA.77

PubChem Substance ID:

24897540

UNSPSC Code:

12352200

MDL number:

MFCD00882995

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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属性

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

off-white

mp

127-128 °C

solubility

DMSO: >5 mg/mL, H₂O: insoluble

SMILES string

CS(=O)(=O)Nc1ccc(cc1OC2CCCCC2)[N+]([O-])=O

InChI

1S/C13H18N2O5S/c1-21(18,19)14-12-8-7-10(15(16)17)9-13(12)20-11-5-3-2-4-6-11/h7-9,11,14H,2-6H2,1H3

InChI key

KTDZCOWXCWUPEO-UHFFFAOYSA-N

Gene Information

human ... ALOX5(240), CYP19A1(1588), PTGS1(5742), PTGS2(5743)
mouse ... Ptgs2(19225)

说明

Application

NS-398作为环氧化酶2(COX2)抑制剂，已用于研究其：

对斑马鱼胚胎心率的作用
对大鼠心肌细胞凋亡和缺氧/复氧的作用
对大鼠脂多糖(LPS)诱导厌食的作用

Biochem/physiol Actions

NS-398属于非甾体抗炎药(NSAID)。具有抗炎、镇痛和退烧作用。

选择性环加氧酶-2（COX-2）抑制剂。

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Prostaglandin E2 contributes to the synthesis of brain-derived neurotrophic factor in primary sensory neuron in ganglion explant cultures and in a neuropathic pain model.

Pedro Cruz Duarte et al.

Experimental neurology, 234(2), 466-481 (2012-02-09)

Brain-derived neurotrophic factor (BDNF) exists in small to medium size neurons in adult rat dorsal root ganglion (DRG) and serves as a modulator at the first synapse of the pain transmission pathway in the spinal dorsal horn. Peripheral nerve injury

Hyperfiltration in ubiquitin C-terminal hydrolase L1-deleted mice.

Naomi C Boisvert et al.

Clinical science (London, England : 1979), 132(13), 1453-1470 (2018-05-10)

Neuronal ubiquitin C-terminal hydrolase L1 (UCHL1) is a deubiquitinating enzyme that maintains intracellular ubiquitin pools and promotes axonal transport. Uchl1 deletion in mice leads to progressive axonal degeneration, affecting the dorsal root ganglion that harbors axons emanating to the kidney.

Gas6 Prevents Epithelial-Mesenchymal Transition in Alveolar Epithelial Cells via Production of PGE2, PGD2 and Their Receptors.

Jihye Jung et al.

Cells, 8(7) (2019-06-30)

The epithelial-mesenchymal transition (EMT) is important in organ fibrosis. We hypothesized that growth arrest-specific protein 6 (Gas6) and its underlying mechanisms play roles in the prevention of EMT in alveolar epithelial cells (ECs). In this study, to determine whether Gas6

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全球贸易项目编号

货号	GTIN
N194-25MG	04061832785707
N194-5MG	04061834109976