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N2915

PYR-41

≥98% (HPLC), powder

别名:

4-[4-[(5-硝基-2-呋喃基)亚甲基]-3,5-二氧代-1-吡唑烷基]苯甲酸乙酯

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关于此项目

经验公式（希尔记法）:
C17H13N3O7
化学文摘社编号:
418805-02-4
分子量:
371.30
UNSPSC Code:
12352200
PubChem Substance ID:
329818421
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

red to brown

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

−20°C

SMILES string

CCOC(=O)c1ccc(cc1)N2NC(=O)\C(=C/c3ccc(o3)[N+]([O-])=O)C2=O

InChI

1S/C17H13N3O7/c1-2-26-17(23)10-3-5-11(6-4-10)19-16(22)13(15(21)18-19)9-12-7-8-14(27-12)20(24)25/h3-9H,2H2,1H3,(H,18,21)/b13-9+

InChI key

ARGIPZKQJGFSGQ-UKTHLTGXSA-N

Application

PYR-41已被用作E1抑制剂：
  • 用于确定腺相关病毒（AAV）转导的细胞降解途径
  • 通过基质辅助激光解吸/电离飞行时间（MALDI-TOF）E2/E3分析，评估其选择性和效力
  • 处理高葡萄糖培养基中完全分化的C2C12肌管，以确定其对蛋白质泛素化和细胞活力的影响
  • 预处理人脑微血管内皮细胞（hBMEC），用于细菌感染前的抑制研究

Biochem/physiol Actions

PYR-41能够抑制E1泛素连接酶，如小鼠双微基因2同源物（MDM2）、痒同源物（ITCH）和HOIL-1L相互作用蛋白（HOIP）的E1泛素连接酶。 它具有潜在的抗癌作用。
PYR-41是泛素活化酶（E1）的细胞渗透性抑制剂.
PYR-41是泛素活化酶（E1）的细胞渗透性抑制剂，对E3、E2或半胱天冬酶的活性几乎无活性或完全无活性。

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302,H317

Hazard Classifications

Acute Tox. 4 Oral - Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
095M4624V
103M4602V
013M4615V
021M4612V

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全球贸易项目编号

货号GTIN
N2915-25MG04061833219737
N2915-5MG04061833219744