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N3538

那格列奈

Name: 那格列奈
Brand: SIGMA

≥98% (HPLC), solid

别名:

Fastic, N-[(trans-4-isopropylcyclohexyl)carbonyl]-D-phenylalanine, Starlix, Starsis

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关于此项目

经验公式（希尔记法）:

C₁₉H₂₇NO₃

化学文摘社编号:

105816-04-4

分子量:

317.42

NACRES:

NA.77

PubChem Substance ID:

329818636

UNSPSC Code:

12352200

MDL number:

MFCD00875706

Assay:

≥98% (HPLC)

Form:

solid

Quality level:

100

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属性

Quality Level

100

assay

≥98% (HPLC)

form

solid

color

white to off-white

solubility

DMSO: >5 mg/mL, H₂O: insoluble

originator

Novartis

storage temp.

room temp

SMILES string

CC(C)[C@@H]1CC[C@H](CC1)C(=O)N[C@H](Cc2ccccc2)C(O)=O

InChI

1S/C19H27NO3/c1-13(2)15-8-10-16(11-9-15)18(21)20-17(19(22)23)12-14-6-4-3-5-7-14/h3-7,13,15-17H,8-12H2,1-2H3,(H,20,21)(H,22,23)/t15-,16-,17-/m1/s1

InChI key

OELFLUMRDSZNSF-BRWVUGGUSA-N

Gene Information

human ... ABCC8(6833), KCNJ11(3767)

说明

Biochem/physiol Actions

Nateglinide is a K_ir6.2/SUR1 channel inhibitor and antidiabetic.

Nateglinide is a Kir6.2/SUR1 channel inhibitor and antidiabetic. It is selective for the SUR1 subtype, which is found on pancreatic islet cells. Nateglinide evokes KATP channel-dependent insulin secretion (50-200 μM) in the absence and presence of insulin.

Nateglinide is a short-acting insulin secretagogue useful in treating type 2 diabetes. It is an insulinotropic agent effective for postprandial hyperglycemia. Nateglinide restores prandial insulin levels in a glucose-dependent manner.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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Potassium Channels

We offer many products related to potassium channels for your research needs.

From evidence assessments to coverage decisions?: the case example of glinides in Germany.

Julia Kreis et al.

Health policy (Amsterdam, Netherlands), 104(1), 27-31 (2011-12-06)

In Germany, coverage decisions in the statutory health insurance (SHI) system are based on the principles of evidence-based medicine. Recently, an evidence assessment by the Institute for Quality and Efficiency in Health Care (IQWiG) of the oral antidiabetics of the

Repaglinide versus nateglinide monotherapy: a randomized, multicenter study.

Julio Rosenstock et al.

Diabetes care, 27(6), 1265-1270 (2004-05-27)

A randomized, parallel-group, open-label, multicenter 16-week clinical trial compared efficacy and safety of repaglinide monotherapy and nateglinide monotherapy in type 2 diabetic patients previously treated with diet and exercise. Enrolled patients (n = 150) had received treatment with diet and

Comparison of the rapidity of onset of the therapeutic effect between nateglinide and mitiglinide by PK/PD analysis in rats.

Toshiyuki Takanohashi et al.

European journal of drug metabolism and pharmacokinetics, 37(1), 9-15 (2011-10-21)

Nateglinide and mitiglinide are immediate short-acting insulinotropic agents. Both are administered preprandially to control postprandial hyperglycemia. Glinide drugs are characterized by immediate onset as well as rapid disappearance of effect as compared with sulfonylurea drugs. We examined the rapidity of

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全球贸易项目编号

货号	GTIN
N3538-10MG	04061834116189
N3538-50MG	04061832575056