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P3371

五氟利多

Name: 五氟利多
Brand: SIGMA

≥97% (HPLC), powder

别名:

1-[4,4-Bis(4-fluorophenyl)butyl]-4-[4-chloro-3(trifluoromethyl)phenyl]-4-piperidinol, R16341

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关于此项目

经验公式（希尔记法）:

C₂₈H₂₇ClF₅NO

化学文摘社编号:

26864-56-2

分子量:

523.97

NACRES:

NA.77

PubChem Substance ID:

329820171

UNSPSC Code:

12352200

EC Number:

248-074-5

MDL number:

MFCD00866714

Assay:

≥97% (HPLC)

Form:

powder

Quality level:

100

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属性

Quality Level

100

assay

≥97% (HPLC)

form

powder

color

white

solubility

DMSO: >20 mg/mL, H₂O: insoluble

originator

Johnson & Johnson

storage temp.

2-8°C

SMILES string

OC1(CCN(CCCC(c2ccc(F)cc2)c3ccc(F)cc3)CC1)c4ccc(Cl)c(c4)C(F)(F)F

InChI

1S/C28H27ClF5NO/c29-26-12-7-21(18-25(26)28(32,33)34)27(36)13-16-35(17-14-27)15-1-2-24(19-3-8-22(30)9-4-19)20-5-10-23(31)11-6-20/h3-12,18,24,36H,1-2,13-17H2

InChI key

MDLAAYDRRZXJIF-UHFFFAOYSA-N

说明

Application

Penfluridol has been used as an antipsychotic agent:

to study its antimetastatic effect on triple-negative breast cancer cells
to study its effects on the growth of glioblastoma cell lines,
to study its effects on the vascular endothelial growth factor (VEGF)-induced angiogenesis in human umbilical vein endothelial cells (HUVECs)

Biochem/physiol Actions

Penfluridol is studied in the treatment of schizophrenia, Tourette syndrome and acute psychosis. It also exhibits anticancer activity.

T-type Ca²⁺channel blocker; antipsychotic

Features and Benefits

This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.