P4912
磷脂酶 D 来源于链霉菌 属
Type VII, lyophilized powder, ≥150 units/mg solid
别名:
Phosphatidylcholine phosphatidohydrolase, 卵磷脂酶 D
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-639-8
MDL number:
Specific activity:
≥150 units/mg solid
Biological source:
Streptomyces sp.
biological source
Streptomyces sp.
Quality Level
type
Type VII
form
lyophilized powder
specific activity
≥150 units/mg solid
storage temp.
−20°C
Application
在 体外 条件下，Sigma的该酶被用于鞘氨酸激酶1 (SK1)向膜组分的转移。它还被用于从HL60透化性细胞中的磷脂酰胆碱(PC)产生磷脂酸(PA)。
脂酶D(PLD)已被用作水解磷脂与鞘磷脂的磷酸键，得到相应的磷脂酸。 它已可用于研究代谢标记和 体内 直接成像胆碱磷脂，通过测量propargyl-cho的掺入。此外，PLD已可用于纯化和动力学研究。
Biochem/physiol Actions
水解磷脂和鞘磷脂的磷酸键，获得相应的磷脂酸。
磷脂酶D是甘油磷脂特异性的。 它对鞘磷脂和溶血磷脂的活性明显降低。 磷脂酶D水解磷脂和鞘磷脂的磷酸键，从而得到相应的磷脂酸。
Packaging
无底玻璃瓶。内容物在插入的熔锥内。
Analysis Note
蛋白质由双缩脲法测定
Other Notes
在pH为 8.0，温度是37 °C的条件下，一个单位酶每小时可从1,2-二油基-{1}sn{2}-甘油-3-磷酸胆碱释放1.0 μmole的胆碱。
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
Kathryn Garner et al.
The Journal of biological chemistry, 287(38), 32263-32276 (2012-07-24)
Phosphatidylinositol transfer proteins (PITPs) are versatile proteins required for signal transduction and membrane traffic. The best characterized mammalian PITPs are the Class I PITPs, PITPα (PITPNA) and PITPβ (PITPNB), which are single domain proteins with a hydrophobic cavity that binds
Christine Delon et al.
The Journal of biological chemistry, 279(43), 44763-44774 (2004-08-18)
Sphingosine kinase 1 (SK1) phosphorylates sphingosine to generate sphingosine 1-phosphate (S1P). Because both substrate and product of the enzyme are potentially important signaling molecules, the regulation of SK1 is of considerable interest. We report that SK1, which is ordinarily a
Franka Voigt et al.
RNA (New York, N.Y.), 18(12), 2128-2134 (2012-10-23)
Piwi-interacting RNAs (piRNAs) are a gonad-specific class of small RNAs that associate with the Piwi clade of Argonaute proteins and play a key role in transposon silencing in animals. Since biogenesis of piRNAs is independent of the double-stranded RNA-processing enzyme
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| P4912-250UN | 04061834375418 |
| P4912-500UN | 04061832759036 |
| P4912-1KU | 04061834375401 |