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P5084

PTIO

Name: PTIO
Brand: SIGMA

NO activity inhibitor, powder

别名:

2-苯基-4,4,5,5-四甲基咪唑啉-1-氧代 3-氧化物

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关于此项目

经验公式（希尔记法）:

C₁₃H₁₇N₂O₂

化学文摘社编号:

18390-00-6

分子量:

233.29

UNSPSC Code:

12352200

PubChem Substance ID:

329820215

NACRES:

NA.32

MDL number:

MFCD00059929

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属性

产品名称

PTIO,

Quality Level

200

form

powder

storage temp.

2-8°C

SMILES string

CC1(C)N([O])C(c2ccccc2)=[N+]([O-])C1(C)C

InChI

1S/C13H17N2O2/c1-12(2)13(3,4)15(17)11(14(12)16)10-8-6-5-7-9-10/h5-9H,1-4H3

InChI key

DYUUGILMVYJEHY-UHFFFAOYSA-N

说明

Application

2-苯基-4，4，5，5，-四甲基咪唑啉-1-氧代 3-氧化物 (PTIO) 已被用作一氧化氮 (NO) 清除剂。

Biochem/physiol Actions

2-苯基-4, 4, 5, 5-四甲基咪唑-1-氧代 3-氧化物 (PTIOs) 衍生物与一氧化氮 (NO) 反应生成相应的的亚氨基氮氧化物 (PTIs) 和二氧化氮 (NO2)。

一种稳定的一氧化氮自由基清除剂；不影响 NO 合成酶而影响 NO；对无生物活性有显著抑制活性。

稳定的一氧化氮自由基清除剂，不影响 NO 合成酶；抑制 NO 活性。

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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In vivo target sites of nitric oxide in photosynthetic electron transport as studied by chlorophyll fluorescence in pea leaves.

Barnabás Wodala et al.

Plant physiology, 146(4), 1920-1927 (2008-02-05)

The role of nitric oxide (NO) in photosynthesis is poorly understood as indicated by a number of studies in this field with often conflicting results. As various NO donors may be the primary source of discrepancies, the aim of this

A protein synthesis and nitric oxide-dependent presynaptic enhancement in persistent forms of long-term potentiation.

Victoria P A Johnstone et al.

Learning & memory (Cold Spring Harbor, N.Y.), 18(10), 625-633 (2011-09-22)

Long-term potentiation (LTP) is an important process underlying learning and memory in the brain. At CA3-CA1 synapses in the hippocampus, three discrete forms of LTP (LTP1, 2, and 3) can be differentiated on the basis of maintenance and induction mechanisms.

NMDA receptor activation enhances inhibitory GABAergic transmission onto hippocampal pyramidal neurons via presynaptic and postsynaptic mechanisms.

Jiu-Gang Xue et al.

Journal of neurophysiology, 105(6), 2897-2906 (2011-04-08)

N-methyl-D-aspartate (NMDA) receptors (NMDARs) are implicated in synaptic plasticity and modulation of glutamatergic excitatory transmission. Effect of NMDAR activation on inhibitory GABAergic transmission remains largely unknown. Here, we report that a brief application of NMDA could induce two distinct actions

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全球贸易项目编号

货号	GTIN
P5084-100MG	04061834375807
P5084-25MG	04061834375821