biological source
rabbit
Quality Level
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, human
technique(s)
immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
mouse ... Il1rl1(17082)
General description
ST2(致癌抑制因子)属于细胞因子IL-1家族。它也称为 IL-33(白细胞介素33)和IL1RL1(白细胞介素1受体样1)。它在巨噬细胞和各种炎症细胞(如辅助性T细胞2(Th2))、肥大细胞、嗜碱细胞和嗜酸粒细胞中表达。它位于染色体2q12。
Immunogen
与小鼠ST2氨基末端16个氨基酸对应的合成肽。该肽序列在三种已知的ST2同种型中共有。
Application
抗-ST2已被用于免疫组化、蛋白质印迹和免疫荧光染色。
Biochem/physiol Actions
ST2(致瘤性抑制)参与哮喘、关节炎、肥胖、动脉粥样硬化等多种疾病的病理生理。它在嗜酸性粒细胞、纤维细胞、内皮细胞中起丝裂原的作用。它有助于Th2淋巴细胞、纤维细胞和内皮细胞的迁移,并可干扰乳腺肿瘤的侵袭和转移。
Physical form
溶剂为含有0.02%叠氮化钠的磷酸盐缓冲盐水
Other Notes
可以使用阻断肽 SBP3363 阻断该抗体的作用。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、体外或体内治疗用途,或人类或动物任何类型的消费或使用。
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
ST2L Transmembrane Receptor Expression: An Immunochemical Study on Endarterectomy Samples
Marzullo A, et al.
PLoS ONE, 11(5) (2016)
The IL-33/ST2 pathway contributes to intestinal tumorigenesis in humans and mice
Mertz KD, et al.
Oncoimmunology, 5(1) (2015)
Xiao-Hui Wang et al.
Molecular medicine reports, 16(4), 3887-3893 (2017-08-03)
Interleukin-33 (IL-33) promotes migration of cancer cells through downregulating the expression of E-cadherin. Previous studies have demonstrated that IL‑33 stimulates the proliferation of trophoblasts. However, the effect of IL‑33 on the adhesion and invasion of trophoblasts has not been investigated
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SBP3363-0.05MG | 04061832180113 |
| PRS3363-100UG | 04061832493473 |