species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
input
sample type: human cell lysate
assay range
inter-assay cv: <10%
intra-assay cv: <12%
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... FER(2241)
General description
FER (fps/fes related) tyrosine kinase is encoded by the gene mapped to human chromosome 5q21.3. Tyrosine kinase is a cytoplasmic protein characterized with a single SH2 domain and an extensive amino terminus. The encoded protein is ubiquitously expressed.
The antibody pair provided in this kit recognizes Human Tyrosine-Phosphorylated-FER.
Application
请参考Protocol了解详情。
Biochem/physiol Actions
FER tyrosine kinase induces signal transduction at the plasma membrane. It is implicated in the regulation of cell-cell adhesion. FER tyrosine kinase interacts with phosphatidic acid (PA) to enhance phosphorylation of cortactin, a protein that promotes actin.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
存储类别
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
A curvature-dependent membrane binding by tyrosine kinase Fer involves an intrinsically disordered region.
Yamamoto H, et al.
Biochemical and Biophysical Research Communications, 495(1), 1522-1527 (2018)
The cytoplasmic tyrosine kinase FER is associated with the catenin-like substrate pp120 and is activated by growth factors.
Kim L and Wong T W
Molecular Cell Biology, 15(8), 4553-4561 (1995)
The Tyrosine Kinase Fer Is a Downstream Target of the PLD-PA Pathway that Regulates Cell Migration
Itoh T, et al.
Science Signaling, 2(87), ra52-ra52 (2009)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| RAB0960-1KT | 04061835167173 |