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SAB1403925

单克隆抗-HMGB1 小鼠抗

Name: 单克隆抗-HMGB1 小鼠抗
Brand: SIGMA

clone 1D5, purified immunoglobulin, buffered aqueous solution

别名:

DKFZp686A04236, HMG1, HMG3, SBP-1

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关于此项目

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

1D5, monoclonal

Application:

ELISA (i), IF, IHC (p), WB

Citations:

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属性

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

1D5, monoclonal

form

buffered aqueous solution

mol wt

antigen ~49.76 kDa

species reactivity

human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, indirect ELISA: suitable, indirect immunofluorescence: suitable, western blot: 1-5 μg/mL

isotype

IgG2aκ

NCBI accession no.

BC003378

UniProt accession no.

P09429

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HMGB1(3146)

说明

Immunogen

HMGB1（AAH03378.1, 1 a.a.~ 215 a.a）带有GST标签的全长重组蛋白。仅GST标签的MW为26 KDa。

序列
MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE

Physical form

溶于pH7.4的磷酸盐缓冲盐水中

Disclaimer

除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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存储类别

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品

低风险生物材料

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

CC12A-1D5

10057-1D5

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Maytansine-bearing antibody-drug conjugates induce in vitro hallmarks of immunogenic cell death selectively in antigen-positive target cells.

Maxine Bauzon et al.

Oncoimmunology, 8(4), e1565859-e1565859 (2019-03-25)

Oncology treatment has been revolutionized by the introduction of immune checkpoint inhibitor drugs, which enable 20-40% of patients to generate anti-tumor immune responses. Combination treatment approaches with chemotherapeutic drugs may enable responses in the remaining patient cohorts. In this regard

Host phenotype is associated with reduced survival independent of tumour biology in patients with colorectal liver metastases.

David P J van Dijk et al.

Journal of cachexia, sarcopenia and muscle, 10(1), 123-130 (2018-11-01)

Most prognostic scoring systems for colorectal liver metastases (CRLMs) account for factors related to tumour biology. Little is known about the effects of the host phenotype to the tumour. Our objective was to delineate the relationship of systemic inflammation and

VCP interaction with HMGB1 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway.

Zhangya Pu et al.

Journal of translational medicine, 20(1), 212-212 (2022-05-14)

Hepatocellular carcinoma (HCC) is the most common pathological type of liver cancer. Valosin-containing protein (VCP) is a member of the AAA-ATPase family associated with multiple molecular functions and involved in tumor metastasis and prognosis. However, the role of VCP in

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全球贸易项目编号

货号	GTIN
SAB1403925-100UG	04061831656244