SAB3500126
ORAI1单克隆抗体 小鼠抗
clone 3F6H5, purified immunoglobulin, buffered aqueous solution
别名:
抗TMEM142A, 抗跨膜蛋白142A, 抗钙释放激活钙通道蛋白1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
3F6H5, monoclonal
Application:
ELISA (i), IF, IHC, WB
Citations:
6
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
3F6H5, monoclonal
form
buffered aqueous solution
mol wt
predicted mol wt 33 kDa
species reactivity
human, rat, mouse
technique(s)
immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ORAI1(84876)
General description
免疫细胞的抗原刺激通过Ca++释放激活的Ca++（CRAC）通道触发Ca++流入。ORAI1是最近发现的一种四跨膜蛋白，它是CRAC的重要组成部分。人体中这种蛋白质的错义突变会引起遗传性严重联合免疫缺陷（SCID），从而导致消融的T细胞Ca++流入。已有研究提出，ORAI1可作为高选择性Ca++质膜通道，通过与STIM1（即存储激活的内质网Ca+传感器）相互作用进行门控。ORAI1在SDS-PAGE中通常以高于预期的分子量迁移。预计该抗体与ORAI2或ORAI3无交叉反应性。
Immunogen
由人ORAI1羧基末端附近的16个氨基酸组成的肽。
Features and Benefits
请完全放心地评估我们的抗体。如果抗体在您的研究中无效，我们将全额退款或换货。了解更多。
Physical form
溶剂为含有0.02％叠氮化钠的1 mg/mL磷酸盐缓冲盐水。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Agnese Secondo et al.
Stroke, 50(5), 1240-1249 (2019-04-23)
Background and Purpose- Disturbance of endoplasmic reticulum (ER) Ca2+ homeostasis causes neuronal cell injury in stroke. By contrast, ischemic preconditioning (IPC)-a brief sublethal ischemic episode affording tolerance to a subsequent ischemic insult-restores ER Ca2+ homeostasis. Under physiological conditions, ER calcium
Gracious R Ross et al.
Biology open, 6(3), 326-332 (2017-01-28)
Excessive cardiac fibrosis, characterized by increased collagen-rich extracellular matrix (ECM) deposition, is a major predisposing factor for mechanical and electrical dysfunction in heart failure (HF). The human ventricular fibroblast (hVF) remodeling mechanisms that cause excessive collagen deposition in HF are
Ana Paula Arruda et al.
eLife, 6 (2017-12-16)
Defective Ca2+ handling is a key mechanism underlying hepatic endoplasmic reticulum (ER) dysfunction in obesity. ER Ca2+ level is in part monitored by the store-operated Ca2+ entry (SOCE) system, an adaptive mechanism that senses ER luminal Ca2+ concentrations through the
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAB3500126-100UG | 04061832494531 |