SAB4200725
抗-剪切因子SC-35抗体，小鼠单克隆
clone SC-35, purified from hybridoma cell culture
别名:
抗-PR264, 抗-SFRS2, 抗-SFRS2A, 抗-SRp30b, 抗-丝氨酸精氨酸二肽富含性剪切因子2(SRSF2), 抗-剪切因子35(SC35)
登录 查看组织和合同定价。
选择尺寸
变更视图
关于此项目
NACRES:
NA.43
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
SC-35, monoclonal
Application:
DB, ELISA, IF, IHC, IP
Citations:
17
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
SC-35, monoclonal
form
buffered aqueous solution
mol wt
~35 kDa
species reactivity
human, mouse, quail, hamster, frog, porcine, rat
concentration
~1.0 mg/mL
technique(s)
ELISA: suitable, dot blot: suitable, immunoblotting: suitable, immunofluorescence: 0.125-0.25 μg/mL using HeLa cells, immunohistochemistry: suitable, immunoprecipitation (IP): suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... SRSF2(6427)
General description
小鼠抗-剪接因子SC-35单克隆抗体（小鼠IgG1同种型）来源于小鼠骨髓瘤细胞与部分纯化剪接体免疫的RBF-DHJ小鼠脾细胞融合产生的SC-35杂交瘤。剪接因子SC-35，也称为丝氨酸精氨酸二肽富含性剪切因子2(SRSF2)，属于丝氨酸精氨酸二肽富含性(SR)蛋白家族。
Immunogen
HeLa细胞制备的部分纯化剪接体
Application
抗-剪接因子SC-35抗体已用于
- 斑点印迹
- 酶联免疫吸附测定(ELISA)
- 免疫荧光
- 免疫组织化学
- 免疫印迹
- 免疫沉淀
Biochem/physiol Actions
剪接因子SC35是pre-mRNA组成性和选择性剪接的重要调控因子。它控制基因毒性应激下的细胞凋亡。丝氨酸/精氨酸蛋白激酶1(SRPK1)可特异性磷酸化SC-35，导致p53抑制和周期蛋白D1上调。SC-35浓度升高与肺鳞状细胞癌和肺腺癌等多种癌症的侵袭性表型有关。SC35在人乳头瘤病毒(HPV)感染细胞的肿瘤进展中起致癌作用。
Physical form
溶于0.01 M磷酸盐缓冲液（pH 7.4）中，含有15 mM叠氮化钠。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的人类或动物食用或应用。
Still not finding the right product?
试用我们的 产品选型工具 工具缩小选择范围
存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Valerie Edmond et al.
The EMBO journal, 30(3), 510-523 (2010-12-16)
SRSF2 is a serine/arginine-rich protein belonging to the family of SR proteins that are crucial regulators of constitutive and alternative pre-mRNA splicing. Although it is well known that phosphorylation inside RS domain controls activity of SR proteins, other post-translational modifications
E2F1 controls alternative splicing pattern of genes involved in apoptosis through upregulation of the splicing factor SC35
Merdzhanova L, et al.
Cell Death and Differentiation, 15(12), 1815-1815 (2008)
D L Spector et al.
The EMBO journal, 10(11), 3467-3481 (1991-11-01)
SC-35 is a non-snRNP spliceosome component that is specifically recognized by the anti-spliceosome monoclonal antibody alpha SC-35. In this paper we provide direct evidence that SC-35 is an essential splicing factor and we examine the immunolocalization of SC-35 by confocal
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAB4200725-100UL | 04061838037794 |