SAB4200764
Anti-Dystrophin Antibody
mouse monoclonal, MANDYS8
别名:
Anti-DMD
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
Clone:
MANDYS8, monoclonal
Species reactivity:
porcine, rabbit, mouse, rat, human
Application:
IHC
Citations:
17
产品名称
Anti-Dystrophin antibody, Mouse monoclonal, clone MANDYS8, purified from hybridoma cell culture
biological source
mouse
Quality Level
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
MANDYS8, monoclonal
form
buffered aqueous solution
mol wt
~427 kDa
species reactivity
porcine, rabbit, mouse, rat, human
enhanced validation
independent
Learn more about Antibody Enhanced Validation
concentration
~1.0 mg/mL
technique(s)
immunoblotting: suitable, immunohistochemistry: 5-10 μg/mL using acetone fixed rat tongue frozen sections
isotype
IgG2b
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... DMD(1756)
General description
Anti-Dystrophin antibody, Mouse monoclonal (mouse IgG2b isotype) is derived from the MANDYS8 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from mouse immunized with fragment of recombinant human dystrophin. Dystrophin is a 427 kD protein which joins the actin cytoskeleton to laminin. It possesses multiple domains and is localized to the extracellular matrix. Dystrophin contains NH2-terminal domain for actin binding. The C-terminal domain interacts with dystrophin associated protein (DAP).
Dystrophin is a rod-shaped cytoskeletal protein located to the periphery (plasma membrane) of normal striated muscle fibers.
Immunogen
recombinant human dystrophin
Application
Anti-Dystrophin antibody, Mouse monoclonal has been used in immunoblotting and immunohistochemistry.
Biochem/physiol Actions
Anti-Dystrophin antibody, Mouse monoclonal specifically recognizes an epitope located on the rod domain of the human dystrophin molecule.
Dystrophin is known to prevent muscle fibre injury due to contraction.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as preservative.
Other Notes
This product is for R&D use only, not for drug, household, or other uses.
存储类别
12 - Non Combustible Liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Anna Cho et al.
Muscle & nerve, 55(5), 727-734 (2016-09-07)
Duchenne and Becker muscular dystrophies (DMD and BMD) are allelic X-linked recessive muscle diseases caused by mutations in the large and complex dystrophin gene. We analyzed the dystrophin gene in 507 Korean DMD/BMD patients by multiple ligation-dependent probe amplification and
Assembly of the dystrophin-associated protein complex does not require the dystrophin COOH-terminal domain
Crawford GF, et al.
The Journal of Cell Biology, 150(6), 1399-1410 (2000)
Applications of CRISPR technologies in research and beyond
Barrangou R and Doudna JA
Nature Biotechnology, 34(9), 933-933 (2016)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SAB4200764-100UL | 04061833265246 |