Anti-phospho-SMAD3 (pSer⁴²⁵) antibody produced in rabbit

Smad3 encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.

The SMAD3 (mothers against decapentaplegic homolog 3) gene is mapped to human chromosome 15q22.33. Smad3 protein identifies tandem repeats of the palindromic sequence GTCTAGAC, which is part of TGF-β (Transforming growth factor β) signaling promoter region.

Peptide sequence around phosphorylation site of serine 425 (C-S-S-V-S(p)), according to the protein SMAD3.

Anti-phospho-SMAD3 (pSer425) antibody produced in rabbit has been used in immunoblotting.

Smad3 (mothers against decapentaplegic homolog 3) is associated with TGF-β (transforming growth factor β) signaling pathway, a cellular process regulating the homeostasis, development, and repair of cartilage. It is known to induce extracellular matrix production. Smad proteins are responsible for the transduction of signals from cell surface to the nucleus. Phosphorylation of Smad3 controls tumor progression, inflammation, fibrosis, obesity and diabetes. Smad3 expression might be associated with the pathogenesis of osteoarthritis.

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Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

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