Anti-RYR2 antibody produced in rabbit

Anti-RYR2 Antibody detects endogenous levels of total RYR2 protein.

RYR2 (ryanodine receptor 2) is an intracellular Ca²⁺ release channel present on the sarcoplasmic reticulum (SR). It forms tetramer with four types 2 RyR polypeptides (RyR2) and four FK506 binding proteins (FKBP12.6).

The antiserum was produced against synthesized peptide derived from human RyR2.

Immunogen Range: 2774-2823

Anti-RYR2 antibody produced in rabbit is suitable for immunohistochemistry and indirect ELISA.

RYR2 (ryanodine receptor 2) provides guidance to the release and transport of Ca²⁺ from sarcoplasmic reticulum (SR) to the cytoplasm during cardiac muscle excitation-contraction (EC) coupling. Protein kinase A (PKA) phosphorylated RYR2 separates (FKBP12.6) to regulate the channel open probability (Po). During the process, a small portion of Ca²⁺ enter into the cell through the L-type Ca²⁺ channel, which further activates the RyR2 channel upon membrane depolarization. The activated RyR2 channel releases a large amount of Ca²⁺ from the SR and subsequent muscle contraction. Missense mutations in this gene cause Kazakh idiopathic ventricular tachycardia and arrhythmogenic right ventricular dysplasia.

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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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