Anti-phospho-Period Circadian Protein 2 (pSer⁶⁶²) antibody produced in rabbit

The PER2 (period circadian regulator 2) gene is mapped to human chromosome 2q37.3.

The antiserum was produced against synthesized peptide derived from human Period Circadian Protein 2 around the phosphorylation site of Ser662.

Immunogen Range: 636-685

PER2 (period circadian regulator 2) possess a physiological and pathological control over the mammalian circadian clock. Abnormal expression of PER2 gene leads to the development of a variety of cancer. Loss of PER2 gene function is observed in the onset of oral squamous cell carcinoma. PER2 might act as an essential biomarker for the same. The reciprocal negative regulation loop of PER2 modulates hepatic circadian clock and the process of aging. PER2 is associated with the pathogenesis of rheumatoid arthritis.

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Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

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