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SML0031

DBeQ

≥98% (HPLC)

别名:

JRF 12, N2，N4-二苄基喹唑啉-2,4-二胺

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关于此项目

经验公式（希尔记法）:
C22H20N4
化学文摘社编号:
177355-84-9
分子量:
340.42
NACRES:
NA.77
PubChem Substance ID:
329825101
UNSPSC Code:
12352200
MDL number:
MFCD03691820
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: ≥20 mg/mL

storage temp.

room temp

SMILES string

C(Nc1nc(NCc2ccccc2)c3ccccc3n1)c4ccccc4

InChI

1S/C22H20N4/c1-3-9-17(10-4-1)15-23-21-19-13-7-8-14-20(19)25-22(26-21)24-16-18-11-5-2-6-12-18/h1-14H,15-16H2,(H2,23,24,25,26)

InChI key

QAIMUUJJAJBPCL-UHFFFAOYSA-N

Application

用DBeQ处理HeLa细胞，并通过活细胞成像对该处理对细胞 体内 泛素化和蛋白质脱位的影响进行了研究。

Biochem/physiol Actions

ATP酶p97抑制剂。
DBeQ是ATP酶p97的有效和特异性抑制剂，ATP酶是泛素-融合降解（UFD）途径的组成部分。DBeQ可抑制泛素化蛋白质的降解、内质网相关的降解途径、以及自噬体成熟。该化合物还可有效抑制细胞增殖并诱导胱天蛋白酶3/7的活性和细胞凋亡。

存储类别

11 - Combustible Solids

wgk

WGK 3

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
086M4751V
055M4726V
054M4715V
121M4713V
051M4738V

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