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关于此项目
经验公式(希尔记法):
C24H29N5O3
化学文摘社编号:
分子量:
435.52
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
缬沙坦, ≥98% (HPLC)
Quality Level
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -55 to -70°, c = 1 in methanol
storage condition
desiccated
color
white to tan
solubility
DMSO: ≥20 mg/mL
originator
Novartis
storage temp.
2-8°C
SMILES string
CCCCC(=O)N(Cc1ccc(cc1)-c2ccccc2-c3nnn[nH]3)[C@@H](C(C)C)C(O)=O
InChI
1S/C24H29N5O3/c1-4-5-10-21(30)29(22(16(2)3)24(31)32)15-17-11-13-18(14-12-17)19-8-6-7-9-20(19)23-25-27-28-26-23/h6-9,11-14,16,22H,4-5,10,15H2,1-3H3,(H,31,32)(H,25,26,27,28)/t22-/m0/s1
InChI key
ACWBQPMHZXGDFX-QFIPXVFZSA-N
Gene Information
human ... AGTR1(185)
Application
使用缬沙坦治疗小鼠,以研究Ang II依赖性途径对醛固酮相关作用的影响。
Biochem/physiol Actions
缬沙坦是一种血管紧张素II 1型(AT1)受体拮抗剂和抗高血压药。缬沙坦可以防止由血压突然升高导致的心脏病发作和中风。 缬沙坦可降低心脏病发作幸存者的心肌梗死相关并发症。
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signalword
Warning
hcodes
Hazard Classifications
Repr. 2 - STOT SE 3
target_organs
Central nervous system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
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Bodh I Jugdutt
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Frédéric Michel et al.
Circulation, 109(16), 1933-1937 (2004-04-14)
We analyzed the role of aldosterone in ischemia-induced neovascularization and the involvement of angiotensin II (Ang II) signaling in this effect. Ischemia was induced by right femoral artery ligature in mice treated or not with aldosterone (4.5 microg/day), aldosterone plus
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML0142-10MG | 04061837076954 |
| SML0142-50MG | 04061837076961 |

