主要文件

查看所有文档

SML0278

SR 48692

Name: SR 48692
Brand: SIGMA

≥98% (HPLC), nonpeptide NT1 neurotensin receptor antagonist , powder

别名:

2-[[[1-(7-Chloro-4-quinolinyl)-5-(2,6-dimethoxyphenyl)-1H-pyrazol-3-yl]carbonyl]amino]-tricyclo[3.3.1.13,7]decane-2-carboxylic acid, Meclinertant

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₃₂H₃₁ClN₄O₅

化学文摘社编号:

146362-70-1

分子量:

587.07

UNSPSC Code:

12352200

PubChem Substance ID:

329825286

NACRES:

NA.77

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

属性

产品名称

SR 48692, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: ≥2 mg/mL (warmed)

storage temp.

−20°C

SMILES string

COc1cccc(OC)c1-c2cc(nn2-c3ccnc4cc(Cl)ccc34)C(=O)NC5(C6CC7CC(C6)CC5C7)C(O)=O

InChI

1S/C32H31ClN4O5/c1-41-27-4-3-5-28(42-2)29(27)26-16-24(36-37(26)25-8-9-34-23-15-21(33)6-7-22(23)25)30(38)35-32(31(39)40)19-11-17-10-18(13-19)14-20(32)12-17/h3-9,15-20H,10-14H2,1-2H3,(H,35,38)(H,39,40)

InChI key

DYLJVOXRWLXDIG-UHFFFAOYSA-N

Gene Information

human ... NTSR1(4923)

说明

Application

SR 48692 has been used as a neurotensin high-affinity receptor 1 (NTSR1) antagonist:

to explore the function of NTSR1 in glioblastoma (GBM) cells
to determine the roles of neurotensin (NT) in the regulation of bile acid (BA) uptake, in vivo
to explore the involvement of NTSR1 versus NTSR2 in mice

Biochem/physiol Actions

SR 48692 is a high affinity, orally bioavailable and selective nonpeptide NT1 neurotensin receptor antagonist that antagonizes neurotensin-induced calcium mobilization with a pA2 of 8.13 in HT-29 human colon carcinoma cell line, and blocks the ability of neurotensin to increase GABA levels in the prefrontal cortex.

SR 48692 is a high affinity, orally bioavailable and selective nonpeptide NT1 neurotensin receptor antagonist.

Features and Benefits

This compound is featured on the Neurotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

037M4737V

094M4726V

032M4753V

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Inhibition of neurotensin receptor 1 selectively sensitizes prostate cancer to ionizing radiation.

Nicholas C K Valerie et al.

Cancer research, 71(21), 6817-6826 (2011-09-10)

Radiotherapy combined with androgen depletion is generally successful for treating locally advanced prostate cancer. However, radioresistance that contributes to recurrence remains a major therapeutic problem in many patients. In this study, we define the high-affinity neurotensin receptor 1 (NTR1) as

Blockade of neurotensin receptors during amphetamine discontinuation indicates individual variability.

Fabiana G Costa et al.

Neuropeptides, 41(2), 83-91 (2007-02-06)

Psychostimulant-induced locomotor sensitization has been related to changes within the mesolimbic dopamine system and has been suggested to be useful to study mechanisms underlying drug craving. Neurotensin is a neuropeptide co-localized with dopamine in the mesolimbic system. The response to

Neurotensin modulation of acetylcholine, GABA, and aspartate release from rat prefrontal cortex studied in vivo with microdialysis.

Polina Petkova-Kirova et al.

Brain research bulletin, 77(2-3), 129-135 (2008-08-30)

The effects of the peptide transmitter neurotensin (NT) on the release of acetylcholine (ACh), gamma-aminobutyric acid (GABA), glutamate (Glu), aspartate (Asp), and taurine from the prefrontal cortex (PFC) of freely moving rats were studied by transversal microdialysis. Neurotensin (0.2 and

查看所有相关文献

全球贸易项目编号

货号	GTIN
SML0278-25MG	04061832899602
SML0278-5MG	04061832899619