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SML0536

依法韦伦

≥98% (HPLC), nonnucleoside reverse transcriptase inhibitor (NNRTI), powder

别名:

依法韦伦, (4S)-6-氯-4-（2-环丙基乙炔基）-1,4-二氢-4-（三氟甲基）-2H-3,1-苯并恶嗪-2-酮

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关于此项目

经验公式（希尔记法）:
C14H9ClF3NO2
化学文摘社编号:
154598-52-4
分子量:
315.67
UNSPSC Code:
12352200
PubChem Substance ID:
329825539
NACRES:
NA.77
MDL number:
MFCD05662344
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100
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产品名称

依法韦伦, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -90 to -100°, c = 1 in methanol

color

white to beige

solubility

DMSO: 15 mg/mL, clear

storage temp.

−20°C

SMILES string

ClC1=CC=C2C([C@@](C#CC3CC3)(C(F)(F)F)OC(N2)=O)=C1

InChI

1S/C14H9ClF3NO2/c15-9-3-4-11-10(7-9)13(14(16,17)18,21-12(20)19-11)6-5-8-1-2-8/h3-4,7-8H,1-2H2,(H,19,20)/t13-/m0/s1

InChI key

XPOQHMRABVBWPR-ZDUSSCGKSA-N

General description

具有Sustiva™商品名的依法韦仑是一种含有苯和恶嗪-2-酮发色团的多环芳烃。

Application

依法韦仑已用于：
  • 评估其抗猪内源性逆转录病毒（PERV）活性
  • 细胞毒性检测
  • 通过结合时间密度泛函理论（TD-DFT）和光谱计算的方法，研究依法韦仑的溶质-溶剂效应

Biochem/physiol Actions

依法韦仑是一种非核苷类逆转录酶抑制剂（NNRTI）。它是一种抗HIV药物，常用于AIDs治疗的联合疗法。它是用于治疗人类免疫缺陷病毒（HIV）1型的高效抗逆转录病毒疗法（HAART）的一部分。
依法韦仑是一种非核苷类逆转录酶抑制剂（NNRTI）；抗逆转录病毒。

Features and Benefits

这种化合物是 ADME 毒性研究的特色产品。点击此处发现更多特色 ADME 毒性产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

Legal Information

Sustiva is a trademark of E. I. du Pont de Nemours and Company

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Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
076M4705V
016M4752V
025M4763V
074M4712V
103M4730V

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Efavirenz is an inducer of drug metabolism enzymes. We studied the effect of efavirenz and ritonavir-boosted darunavir on serum unconjugated and conjugated bilirubin, as probes for UGT1A1 and bile transporters. Healthy volunteers were enrolled in a clinical trial. There were
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Rochelle P Walensky et al.
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货号GTIN
SML0536-10MG04061837084799
SML0536-50MG04061832633749