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SML2195

AZD6482

Name: AZD6482
Brand: SIGMA

≥98% (HPLC)

别名:

(-) 2-[1-(7-methyl-2-(morpholin-4-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl)ethylamino]benzoic acid, 2-[[(1R)-1-[7-Methyl-2-(4-morpholinyl)-4-oxo-4H-pyrido[1,2-a]pyrimidin-9-yl]ethyl]amino]-benzoic acid, AZD 6482

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关于此项目

经验公式（希尔记法）:

C₂₂H₂₄N₄O₄

化学文摘社编号:

1173900-33-8

分子量:

408.45

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD16659062

Assay:

≥98% (HPLC)

Form:

powder

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属性

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 2 mg/mL, clear

storage temp.

−20°C

SMILES string

[n]21c(nc(c[c]2=O)N4CCOCC4)c(cc(c1)C)[C@H](Nc3c(cccc3)C(=O)O)C

InChI

1S/C22H24N4O4/c1-14-11-17(15(2)23-18-6-4-3-5-16(18)22(28)29)21-24-19(12-20(27)26(21)13-14)25-7-9-30-10-8-25/h3-6,11-13,15,23H,7-10H2,1-2H3,(H,28,29)/t15-/m1/s1

InChI key

IRTDIKMSKMREGO-OAHLLOKOSA-N

说明

Biochem/physiol Actions

AZD6482 is an isoform-selective and potent ATP competitive inhibitor of PI3Kb. AZD6482 produces an antithrombotic effect without an increased bleeding time or blood loss in humans and in dogs.

isoform-selective and potent ATP competitive inhibitor of PI3Kb

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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PI3K pathway dependencies in endometrioid endometrial cancer cell lines.

Britta Weigelt et al.

Clinical cancer research : an official journal of the American Association for Cancer Research, 19(13), 3533-3544 (2013-05-16)

Endometrioid endometrial cancers (EEC) frequently harbor coexisting mutations in phosphoinositide 3-kinase (PI3K) pathway genes, including PTEN, PIK3CA, PIK3R1, and KRAS. We sought to define the genetic determinants of PI3K pathway inhibitor response in EEC cells, and whether PTEN-mutant EEC cell

Addition of the p110α inhibitor BYL719 overcomes targeted therapy resistance in cells from Her2-positive-PTEN-loss breast cancer.

Chen Zhang et al.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 37(11), 14831-14839 (2016-09-19)

Breast cancer is one of the leading causes of death for women worldwide. Among various subtypes of breast cancer, human epidermal growth factor receptor 2 (HER2)-positive and phosphatase and tensin homolog (PTEN) loss breast cancer is a cause of great

Human target validation of phosphoinositide 3-kinase (PI3K)β: effects on platelets and insulin sensitivity, using AZD6482 a novel PI3Kβ inhibitor.

S Nylander et al.

Journal of thrombosis and haemostasis : JTH, 10(10), 2127-2136 (2012-08-22)

Based on in vitro and animal data, PI3Kβ is given an important role in platelet adhesion and aggregation but its role in insulin signaling is unclear. To strengthen the PI3Kβ target validation using the novel, short-acting inhibitor AZD6482. AZD6482 is

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全球贸易项目编号

货号	GTIN
SML2195-25MG	04061835303601
SML2195-5MG	04061835303618

主要文件

AZD6482

≥98% (HPLC)

选择尺寸

关于此项目

assay

form

color

solubility

storage temp.

SMILES string

InChI

InChI key

Biochem/physiol Actions

安全信息

存储类别

wgk

flash_point_f

flash_point_c

法规信息

文件

分析证书(COA)

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全球贸易项目编号