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SRP0109

HDAC-7 human

Name: HDAC-7 human
Brand: SIGMA

recombinant, expressed in baculovirus infected insect cells, ≥70% (SDS-PAGE)

别名:

HD7, HD7A, HDAC7A, Histone deacetylase 7

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关于此项目

NACRES:

NA.32

UNSPSC Code:

12352200

Biological source:

human

Recombinant:

expressed in baculovirus infected insect cells

Assay:

≥70% (SDS-PAGE)

Form:

aqueous solution

Mol wt:

78 kDa

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属性

biological source

human

recombinant

expressed in baculovirus infected insect cells

assay

≥70% (SDS-PAGE)

form

aqueous solution

potency

≥10 units/mg

mol wt

78 kDa

packaging

pkg of 2 and 10 μg

storage condition

avoid repeated freeze/thaw cycles

concentration

>0.02 mg/mL

NCBI accession no.

AY302468

UniProt accession no.

Q8WUI4

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... HDAC7(51564)

说明

General description

HDAC7 (histone deacetylase 7) is located on human chromosome 12q13. It is expressed in fetal and adult pre-B cells.

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Biochem/physiol Actions

Histone deacetylases (HDACs) play crucial roles in the epigenetic modulation of gene expression and helps in the growth, differentiation, and apoptosis of cancer cells. Knockdown of HDAC7 stimulates apoptosis and autophagy in salivary mucoepidermoid carcinoma cells. It may play a vital role in both types of B lymphopoiesis. HDAC7 serves as a repressor of myeloid genes.

Physical form

Formulated in 25 mM Tris-HCl, pH 8.0, 138 mM NaCl, 0.05% Tween-20 and 10% glycerol.

Preparation Note

Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.

Other Notes

One unit is defined as the amount of enzyme required to deacetylate 1 pmol of substrate/min at 37°C.

存储类别

12 - Non Combustible Liquids

wgk

WGK 1

法规信息

常规特殊物品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

50007100527

5000700527

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Histone deacetylase 7 silencing induces apoptosis and autophagy in salivary mucoepidermoid carcinoma cells.

Ahn MY & Yoon JH

Journal of Oral Pathology & Medicine, 46(4), 276-283 (2017)

Overview of the classical histone deacetylase enzymes and histone deacetylase inhibitors.

Ververis K & Karagiannis TC

ISRN Cell Biology , 2012 (2012)

HDAC7 is a repressor of myeloid genes whose downregulation is required for transdifferentiation of pre-B cells into macrophages.

Bruna Barneda-Zahonero et al.

PLoS genetics, 9(5), e1003503-e1003503 (2013-05-23)

B lymphopoiesis is the result of several cell-commitment, lineage-choice, and differentiation processes. Every differentiation step is characterized by the activation of a new, lineage-specific, genetic program and the extinction of the previous one. To date, the central role of specific

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