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SRP0127

DNMT2 Active human

Name: DNMT2 Active human
Brand: SIGMA

recombinant, expressed in baculovirus infected insect cells, ≥80% (SDS-PAGE)

别名:

DNA (cytosine-5-)-methyltransferase 2, PUMET, RNMT1, tRNA (cytosine-5-)-methyltransferas, tRNA aspartic acid methyltransferase 1

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关于此项目

NACRES:

NA.32

UNSPSC Code:

12352200

Assay:

≥80% (SDS-PAGE)

Biological source:

human

Recombinant:

expressed in baculovirus infected insect cells

Concentration:

>0.02 mg/mL

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属性

biological source

human

recombinant

expressed in baculovirus infected insect cells

assay

≥80% (SDS-PAGE)

form

aqueous solution

mol wt

71 kDa

packaging

pkg of 10 μg

concentration

>0.02 mg/mL

NCBI accession no.

NM_004412

UniProt accession no.

Q6ICS7

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... TRDMT1(1787)

说明

General description

DNA (cytosine-5-)-methyltransferase 2 (DNMT2) is a highly conserved protein which is part of the DNA methyltransferase family. It possesses a conserved cysteine residue in its catalytic pocket. The gene encoding it is localized on human chromosome 10p14->p12.

Application

Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.

Biochem/physiol Actions

DNA (cytosine-5-)-methyltransferase 2 (DNMT2) methylates the cytosine-38 residue of the aspartic acid transfer RNA (tRNA-Asp). It has been shown to interact with the anticodon stem and loop. The protein also functions in cellular physiology and stress response. It is significantly expressed in cancers.

Physical form

Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20 and 10% glycerol.

Preparation Note

Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.

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分析证书(COA)

Lot/Batch Number

51102090513

5110290513

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Azacytidine Inhibits RNA Methylation at DNMT2 Target Sites in Human Cancer Cell Lines

Matthias Schaefer

Cancer Research, 69(20) (2009)

Human DNMT2 methylates tRNAAsp molecules using a DNA methyltransferase-like catalytic mechanism

Tomasz P. Jurkowski

RNA, 14(8), 1663-1670 (2008)

Assignment1 of candidate DNA methyltransferase gene (DNMT2) to human chromosome band 10p15.1 by in situ hybridization

Vilain A

Cytogenetic and genome research, 82 (1998)

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全球贸易项目编号

货号	GTIN
SRP0127-10UG	04061837111518