biological source
human
recombinant
expressed in E. coli
assay
≥98% (SDS-PAGE)
form
lyophilized
potency
<1.0 ng/mL ED50
mol wt
(Noncovalent Homodimer, 13.6 kDa (121 amino acids))
packaging
pkg of 20 μg
technique(s)
cell culture | mammalian: suitable
impurities
<0.1 EU/μg endotoxin, tested
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... NGF(4803)
General description
β-NGF 是与 BDNF、NT-3 和 NT-4 结构相关的神经营养因子。这些蛋白质属于生长因子的半胱氨酸结家族，其具有稳定的二聚体结构。β-NGF 是一种强神经营养因子，通过其受体 β-NGFR 传递信号，在感觉和交感神经系统的发育和保存中起着至关重要的作用。β-NGF 还作为 B 淋巴细胞的生长和分化因子，并促进 B 细胞的存活。人 β-NGF 的功能形式是非共价二硫键连接的同源二聚体，具有两个 13.5kDa 多肽单体（总共 240 个氨基酸残基）。这三个二硫键是生物活性所必需的。
Application
人β NGF 已被用于免疫组织化学。
Biochem/physiol Actions
β-NGF 是与 BDNF、NT-3 和 NT-4 结构相关的神经营养因子。人 b-NGF 的功能形式是非共价二硫键连接的同源二聚体，具有两个 13.5kDa 多肽单体（总共 240 个氨基酸残基）。这三个二硫键是生物活性所必需的。
Physical form
冻干品，无添加剂。
Preparation Note
在打开之前离心小瓶。在水中重悬至浓度为 0.1-1.0 mg/ml。不要涡旋。该溶液可在 2-8℃ 下储存长达 1 周。要于长期储存，建议在含有载体蛋白（例如 0.1％ BSA）的缓冲液中进一步稀释，并以 工作等分试样储存于 -20°C 至 -80°C。
Other Notes
SSSHPIFHRG EFSVCDSVSV WVGDKTTATD IKGKEVMVLG EVNINNSVFK QYFFETKCRD PNPVDSGCRG IDSKHWNSYC TTTHTFVKAL TMDGKQAAWR FIRIDTACVC VLSRKAVRRA
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
H Zhang et al.
European journal of histochemistry : EJH, 59(3), 2522-2522 (2015-10-03)
The nerve growth factor (NGF) not only has an essential effect on the nervous system, but also plays an important role in a variety of non-neuronal systems, such as the reproductive system. The aim of this study was to investigate
A Ullrich et al.
Nature, 303(5920), 821-825 (1983-06-30)
Nerve growth factor (NGF) is thought to have a profound effect on the development and maintenance of sympathetic and embryonic sensory neurones (see refs 1-3 for review). NGF activity isolated from the male mouse submaxillary gland (MSG) consists of three
The nerve growth factor 35 years later.
R Levi-Montalcini
Science (New York, N.Y.), 237(4819), 1154-1162 (1987-09-04)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SRP3015-20UG | 04061837202506 |