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T3955

TNP

Name: TNP
Brand: SIGMA

≥95% (HPLC), IP6K inhibitor, powder

别名:

N2-（间三氟苄基），N6-（对硝基苄基）嘌呤; N6-[（4-硝基苯基）甲基] -N2-[[3-（三氟甲基）苯基]甲基] -9H-嘌呤-2,6-二胺；N6-[（4-硝基苯基）甲基] -N2-[[3-（三氟甲基）苯基]甲基] -1H-嘌呤-2,6-二胺

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关于此项目

经验公式（希尔记法）:

C₂₀H₁₆F₃N₇O₂

化学文摘社编号:

519178-28-0

分子量:

443.38

UNSPSC Code:

12352200

PubChem Substance ID:

329826781

NACRES:

NA.77

MDL number:

MFCD16875436

Assay:

≥95% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

protect from light

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属性

产品名称

TNP, ≥95% (HPLC)

Quality Level

100

assay

≥95% (HPLC)

form

powder

storage condition

protect from light

color

yellow

solubility

DMSO: ≥10 mg/mL

originator

Novartis

storage temp.

2-8°C

SMILES string

[O-][N+](=O)c1ccc(CNc2nc(NCc3cccc(c3)C(F)(F)F)nc4[nH]cnc24)cc1

InChI

1S/C20H16F3N7O2/c21-20(22,23)14-3-1-2-13(8-14)10-25-19-28-17(16-18(29-19)27-11-26-16)24-9-12-4-6-15(7-5-12)30(31)32/h1-8,11H,9-10H2,(H3,24,25,26,27,28,29)

InChI key

DDSBPUYZPWNNGH-UHFFFAOYSA-N

说明

Biochem/physiol Actions

TNP是一种有效的选择性IP6K抑制剂；选择性较低的IP3K抑制剂。 2002年首次报道了TNP作为肌醇三磷酸（IP3）激酶抑制剂的发现，但是，最近的参考资料显示TNP作为IP6K抑制剂更有效，这使其对于肌醇焦磷酸盐的研究具有重要意义。

有效和选择性的IP6K抑制剂；选择性较低的IP3K抑制剂。

Features and Benefits

该化合物由 Novartis 开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单，请单击此处。

Preparation Note

TNP可溶于DMSO，溶解浓度大于等于10 mg/ml。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

115M4602V

013M4608V

010M4609

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Eosinophils Mediate Basophil-Dependent Allergic Skin Inflammation in Mice.

Joerg U Eberle et al.

The Journal of investigative dermatology, 139(9), 1957-1965 (2019-03-27)

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Identifying trade-offs between biodiversity conservation and ecosystem services delivery for land-use decisions.

Constance Fastré et al.

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Sustainable land-use management must account for the potential trade-offs between biodiversity conservation, productive land uses and ecosystem services. In this study, we used Marxan with Zones to generate land use plans that optimize conservation, farming and forestry land uses to

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全球贸易项目编号

货号	GTIN
T3955-25MG	04061833226803
T3955-5MG	04061833226810