Quality Level
assay
≥98% (HPLC)
form
powder
color
red
solubility
DMSO: 1 mg/mL
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
SMILES string
Cc1coc2-c3ccc4c(C)cccc4c3C(=O)C(=O)c12
InChI
1S/C18H12O3/c1-9-4-3-5-12-11(9)6-7-13-15(12)17(20)16(19)14-10(2)8-21-18(13)14/h3-8H,1-2H3
InChI key
AIGAZQPHXLWMOJ-UHFFFAOYSA-N
General description
Tanshinone I （Tan I）是一种酚类化合物，主要由丹参（Danshen）中分离。它具有松香烷二萜降三萜o-醌结构。Tan I的水溶性较差。
Application
Tanshinone 1 已被用于：
- 测定其对人白血病细胞系和斑马鱼异种肿瘤移植模型的造血作用
- 研究其对两种乳腺癌细胞系（MCF7 和MDA-MB-23）的抗癌作用
- 作为标准品通过高效液相色谱（(HPLC）法定量测定丹参提取物（SME）的生物活性成分
Biochem/physiol Actions
中药丹参（Salvia miltiorrhiza）中的菲醌成分。 通过调节粘附分子来调节或预防乳腺癌转移。抗炎症。
研究人员广泛研究了TanshinoneI的抗癌特性。据报道它抑制癌症侵袭、转移和迁移，是强效抗肿瘤剂。它还具有抗菌、神经保护、改善记忆和心血管保护活性。
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Xiao Zhang et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 48(4-5), 595-603 (2013-01-29)
The aim of this study was to develop novel multiple agents loaded poly (D,L-lactide-co-glycolide acid) (PLGA) nanoparticles (NPs) and evaluate their potential for brain delivery via inner ear administration. PLGA NPs loaded with salvianolic acid B (Sal B), tanshinone IIA
Hui Ma et al.
The American journal of Chinese medicine, 41(1), 197-210 (2013-01-23)
Natural product Tanshinone IIA (TanIIA) induces apoptosis and differentiation in hepatocellular carcinoma (HCC) cells, but its clinical use is limited due to poor water solubility and lack of appropriate formulations for drug delivery. In this study, we capsulated TanIIA into
Paul Chan et al.
The American journal of Chinese medicine, 40(6), 1307-1319 (2012-12-12)
The injury of endothelial cell is the critical event of vascular disease. In endothelial cell, oxidative stress is regarded as critical to pathogenic factors in endothelial cell injury and apoptosis. Tanshinone IIA is the main effective component of Salvia miltiorrhiza
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T5330-25MG | 04061832412023 |
| T5330-5MG | 04061832412030 |