W2270
Wiskostatin
别名:
1-（3,6-二溴卡巴唑-9-基）-3-（二甲氨基）丙-2-醇
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关于此项目
经验公式（希尔记法）:
C17H18Br2N2O
化学文摘社编号:
分子量:
426.15
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
assay
≥98% (HPLC)
Quality Level
form
powder
color
white to beige
solubility
DMSO: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
CN(C)CC(O)Cn1c2ccc(Br)cc2c3cc(Br)ccc13
InChI
1S/C17H18Br2N2O/c1-20(2)9-13(22)10-21-16-5-3-11(18)7-14(16)15-8-12(19)4-6-17(15)21/h3-8,13,22H,9-10H2,1-2H3
InChI key
XUBJEDZHBUPBKL-UHFFFAOYSA-N
General description
Wiskostatin是一种二溴化咔唑。其N-烷基化侧链包含一个手性羟基和一个末端叔胺。
Application
Wiskostatin已被用于：
- 在人骨肉瘤 U2OS 细胞和小鼠尾成纤维细胞系中作为 Wiskott-Aldrich 综合征蛋白 (WASP) 的小分子抑制剂
- 作为培养神经元 以及在表达 HA-Parkin 的人胚胎肾 (HEK293) 细胞中的神经 (N)-WASP抑制剂
- 作为背根神经节 (DRG) 细胞中的神经 (N)-WASP 抑制剂，研究血管内皮生长因子 (VEGF) 对肌动蛋白相关蛋白 2/3 复合物 (Arp 2/3) 的影响
Biochem/physiol Actions
Wiskostatin 是 N-WASP 的选择性抑制剂，N-WASP 是 Wiskott-Aldrich 综合征蛋白 (WASP) 家族中广泛表达的成员，调控肌动蛋白聚合。
Wiskostatin 是 N-WASP 的选择性抑制剂，N-WASP 是 Wiskott-Aldrich 综合征蛋白 (WASP) 家族中广泛表达的成员，调控肌动蛋白聚合。维司他丁抑制肌动蛋白依赖性细胞功能，包括迁移、跨膜转运和吞噬作用。
Wiskostatin可介导胞质分裂的抑制作用。它可与 WASP 相互作用，尤其是与调节鸟苷-5′-三磷酸 (GTP) 酶结合域 (GBD)发生结合。
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Chronic 4
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
Guillaume Bompard et al.
BMC cell biology, 9, 42-42 (2008-08-01)
Cytokinesis is the final step of cell division taking place at the end of mitosis during which the cytoplasmic content and replicated chromosomes of a cell are equally partitioned between the two daughter cells. This process is achieved by the
Chaohong Liu et al.
PLoS biology, 11(11), e1001704-e1001704 (2013-11-14)
Negative regulation of receptor signaling is essential for controlling cell activation and differentiation. In B-lymphocytes, the down-regulation of B-cell antigen receptor (BCR) signaling is critical for suppressing the activation of self-reactive B cells; however, the mechanism underlying the negative regulation
Astrid Escudero-Esparza et al.
Journal of experimental & clinical cancer research : CR, 31, 43-43 (2012-05-09)
Recent studies have shown dysregulation in TJ structure of several cancers including breast. Claudin-5 is a protein member of the TJ structure expressed in both endothelial and epithelial cells. This study examined the level of expression and distribution of Claudin-5
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| W2270-25MG | 04061833227107 |
| W2270-5MG | 04061833227114 |