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关于此项目
线性分子式:
C28 H50 N2 O2
化学文摘社编号:
分子量:
446.71
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Form:
film
Quality level:
产品名称
光溜海绵素C, film
form
film
Quality Level
color
colorless
solubility
DMSO: soluble
shipped in
dry ice
storage temp.
−20°C
SMILES string
[H][C@@]12CCCCCC[C@@]3([H])CCCN4CC[C@@]([H])(CCCCCC[C@]5([H])CCCN(CC1)[C@@]5([H])O2)O[C@@]34[H]
InChI
1S/C28H50N2O2/c1-3-7-15-25-17-21-30-20-10-14-24(28(30)31-25)12-6-2-4-8-16-26-18-22-29-19-9-13-23(11-5-1)27(29)32-26/h23-28H,1-22H2/t23-,24+,25-,26-,27+,28+/m1/s1
InChI key
PQYOPBRFUUEHRC-HCKQMYSWSA-N
General description
从 Okanowan 海洋海绵中分离得到的大环双-1-氧喹啉脒的合成形式。
Biochem/physiol Actions
Xestospongin C 是 IP 3 介导的 Ca 2 + 释放 (IC 50 = 358 nM) 的强效、可逆和膜渗透性阻断剂。
Xestospongin C 是 IP 3 受体的选择性、可逆性和膜通透性抑制剂。可逆地阻断缓激肽-和氨甲酰胆碱-Ca 2 + 从内质网储存中流出。
Features and Benefits
《受体分类和信号转导》手册的 InsP3/Ryanodine 受体页有该化合物的介绍。想要浏览手册的其他页面, 请单击此处。
Packaging
氮气中包装,密封。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Human immunodeficiency virus-1 (HIV-1) infection compromises the central nervous system (CNS) in a significant number of infected individuals, resulting in neurological dysfunction that ranges from minor cognitive deficits to frank dementia. While macrophages/microglia are the predominant CNS cells infected by
D B van Rossum et al.
The Journal of biological chemistry, 275(37), 28562-28568 (2000-07-06)
The mechanism for coupling between Ca(2+) stores and store-operated channels (SOCs) is an important but unresolved question. SOC-mediated Ca(2+) entry is complex and may reflect more than one type of channel and coupling mechanism. To assess such possible divergence the
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| X2628-10UG | 04061837545474 |
| X2628-50UG | 04061833632710 |