X4626
XTT 钠盐
powder, BioReagent, suitable for cell culture
别名:
2,3-双(2-甲氧基-4-硝基-5-磺苯基)-2H-四氮唑-5-甲酰苯胺 内盐
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关于此项目
经验公式（希尔记法）:
C22H16N7NaO13S2
化学文摘社编号:
分子量:
673.52
NACRES:
NA.75
PubChem Substance ID:
UNSPSC Code:
12352207
MDL number:
product line
BioReagent
Quality Level
assay
≥90%
form
powder
storage condition
dry at room temperature
technique(s)
cell culture | mammalian: suitable, protein quantification: suitable
application(s)
detection
detection method
colorimetric
storage temp.
2-8°C
SMILES string
[Na+].COc1cc(c(cc1-n2nc(n[n+]2-c3cc(c(cc3OC)[N+]([O-])=O)S([O-])(=O)=O)C(=O)Nc4ccccc4)S([O-])(=O)=O)[N+]([O-])=O
InChI
1S/C22H17N7O13S2.Na/c1-41-17-8-15(28(31)32)19(43(35,36)37)10-13(17)26-24-21(22(30)23-12-6-4-3-5-7-12)25-27(26)14-11-20(44(38,39)40)16(29(33)34)9-18(14)42-2;/h3-11H,1-2H3,(H2-,23,30,35,36,37,38,39,40);/q;+1/p-1
InChI key
JACYMBNQPPWQML-UHFFFAOYSA-M
General description
XTT（3′-[1-[(苯胺基)-羰基]-3,4-四唑]-双(4-甲氧基-6-硝基)苯-磺酸钠）是一种四唑盐，在生物还原时可生成水溶性甲臜。
Application
XTT钠盐已用于评估细胞活性。
XTT可与吩嗪硫酸甲酯（PMS）联合使用，用于筛选人肿瘤细胞系。 四唑染料也被用于真菌细胞损伤研究 、葡萄球菌的抗菌敏感性测试，以及念珠菌生物膜研究。XTT检测法的局限性也有报道。
Biochem/physiol Actions
XTT（3′-[1-[(苯胺基)-羰基]-3,4-四唑]-双(4-甲氧基-6-硝基)苯-磺酸钠）受到代谢活性细胞中存在的脱氢酶的作用。这可产生水溶性甲臜，是一种颜色很深的产物。因为产物是可溶的，不会形成甲臜结晶，这一点与MTT相反，因此XTT在细胞增殖比色法检测中更具优势。
在活细胞中，XTT被代谢还原，生成可比色的水溶性甲臜产物。
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signalword
Danger
hcodes
Hazard Classifications
Self-react. C
supp_hazards
存储类别
4.1A - Other explosive hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Innovative method for quantification of cell-cell adhesion in 96-well plates
Zepeda-Moreno A, et al.
Cell adhesion & migration, 5(3), 215-219 (2011)
L M Jost et al.
Journal of immunological methods, 147(2), 153-165 (1992-03-04)
A tetrazolium compound, XTT, bioreducible to a water-soluble formazan was used to develop a simplified cellular cytotoxicity assay. Most (13/15 melanoma and 2/3 colon carcinoma cell lines tested metabolized XTT greater than 50 times more efficiently than the lymphoid effector
Amos C Hung et al.
Oncology letters, 22(5), 774-774 (2021-10-01)
Esophageal cancer is one of the most common malignancies and leading cause of cancer-associated mortality worldwide. However, the molecular mechanisms underlying esophageal cancer progression and the development of clinical tools for effective diagnosis remain unclear. Resistin, which was originally identified
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| X4626-100MG | 04061835514243 |
| X4626-500MG | 04061835514250 |