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Merck
CN

1148089

USP

胶原酶I

United States Pharmacopeia (USP) Reference Standard

别名:

胶原酶 来源于溶组织梭菌, 梭菌肽酶 A

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关于此项目

化学文摘社编号:
UNSPSC Code:
41116107
NACRES:
NA.24
MDL number:
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grade

pharmaceutical primary standard

form

liquid

manufacturer/tradename

USP

application(s)

USP Biologics
pharmaceutical

format

neat

General description

Collagenase I is an enzyme that breaks down collagen, a primary structural protein in connective tissues. It is used in various medical and research applications, including tissue dissociation and wound debridement.​

The USP Collagenase I standard provides a benchmark for the activity and purity of collagenase I, ensuring its efficacy and safety in therapeutic and laboratory settings.

The USP biologics proteins category provides critical standards and reference materials necessary for the development and manufacturing of therapeutic proteins. These proteins, which can be naturally derived or genetically engineered, are essential in treating various diseases and conditions, ensuring that they meet quality, safety, and efficacy standards.

The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.

Biochem/physiol Actions

每摩尔胶原蛋白酶被4g原子钙活化。 它被乙二醇-双(β-氨基乙基醚)-N,NN′,N′-四乙酸,β-巯基乙醇、谷胱甘肽、巯基乙酸和8-羟基喹啉抑制。

Analysis Note

这些产品仅供测试和分析使用。它们不适用于人类或动物的给药,不可用于诊断、治疗或治愈任何疾病。  ?

Other Notes

一个胶原蛋白消化单元(CDU)从牛跟腱胶原蛋白中释放的肽链量和1.0 μ亮氨酸,5小时,pH7.4,37℃,在钙离子存在下的茚三酮颜色相同。一个 FALGPA水解单元每分钟,25℃,水解1.0 μmole 呋喃基丙烯酰-Leu-Gly-Pro-Ala。一个中性蛋白酶单元水解酪蛋白,产生颜色和1.0 μmole 酪氨酸每5小时,pH7.5,37℃下产生的相同。一个梭菌蛋白酶单元在DTT存在下,pH7.6,25℃,每分钟水解1.0 μmole BAEE。
可能适用相应的销售限制。
该产品是美国药典生物制品计划的一部分。
This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including MSDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.


pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Resp. Sens. 1

存储类别

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

常规特殊物品

此项目有



历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Junaid Akhtar et al.
Bio-protocol, 10(4), e3520-e3520 (2021-03-04)
Chromatin immunoprecipitation is extensively used to investigate the epigenetic profile and transcription factor binding sites in the genome. However, when the starting material is limited, the conventional ChIP-Seq approach cannot be implemented. This protocol describes a method that can be



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货号GTIN
1148089-2X0.5ML04061834098270