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1289003

USP

庆大霉素硫酸盐

Name: 庆大霉素 硫酸盐
Brand: USP

United States Pharmacopeia (USP) Reference Standard

别名:

Gentamicin sulfate salt, Gentamicin C complex sulfate.

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关于此项目

化学文摘社编号:

1405-41-0

PubChem Substance ID:

329749933

UNSPSC Code:

41116107

NACRES:

NA.24

EC Number:

215-778-9

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属性

grade

pharmaceutical primary standard

API family

gentamicin

form

powder

manufacturer/tradename

USP

application(s)

USP Biologics
pharmaceutical (small molecule)

format

neat

SMILES string

O=S(O)(O)=O.O[C@]1(C)[C@@H]([C@@H](O)[C@@H](O[C@@H]2[C@@H](O)[C@H](O[C@H]3O[C@@](CC[C@H]3N)([C@@H](C)NC)[H])[C@@H](N)C[C@H]2N)OC1)NC.O[C@]4(C)[C@@H]([C@@H](O)[C@@H](O[C@@H]5[C@@H](O)[C@H](O[C@H]6O[C@@](CC[C@H]6N)([C@@H](C)N)[H])[C@@H](N)C[C@H]5N)OC4)NC.O[

InChI

1S/C21H43N5O7.C20H41N5O7.C19H39N5O7.H2O4S/c1-9(25-3)13-6-5-10(22)19(31-13)32-16-11(23)7-12(24)17(14(16)27)33-20-15(28)18(26-4)21(2,29)8-30-20;1-8(21)12-5-4-9(22)18(30-12)31-15-10(23)6-11(24)16(13(15)26)32-19-14(27)17(25-3)20(2,28)7-29-19;1-19(27)7-28-18(13(26)16(19)24-2)31-15-11(23)5-10(22)14(12(15)25)30-17-9(21)4-3-8(6-20)29-17;1-5(2,3)4/h9-20,25-29H,5-8,22-24H2,1-4H3;8-19,25-28H,4-7,21-24H2,1-3H3;8-18,24-27H,3-7,20-23H2,1-2H3;(H2,1,2,3,4)/t9-,10-,11+,12-,13+,14+,15-,16-,17+,18-,19-,20-,21+;8-,9-,10+,11-,12+,13+,14-,15-,16+,17-,18-,19-,20+;8-,9+,10-,11+,12-,13+,14+,15-,16+,17+,18+,19-;/m110./s1

InChI key

RDEIXVOBVLKYNT-HDZPSJEVSA-N

说明

General description

Gentamicin sulfate is a broad-spectrum aminoglycoside antibiotic derived from Micromonospora species. It binds irreversibly to the 30S ribosomal subunit, causing misreading of mRNA and inhibition of protein synthesis. The USP standard is used in microbiological assays and chromatographic analyses of gentamicin-containing products.

The USP biologics antibiotics category includes a wide range of antimicrobial agents that are essential in treating bacterial infections. These antibiotics are derived from various natural sources or synthesized to combat specific pathogens effectively. The USP provides comprehensive standards, reference materials, and analytical procedures to ensure the identity, quality, purity, and consistency of antibiotic therapeutics throughout their lifecycle.

The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.

Application

Gentamicin sulfate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.
Also, for use with USP monographs such as:

Gentamicin Sulfate Cream
Gentamicin Sulfate Ointment
Gentamicin Sulfate Ophthalmic Ointment
Gentamicin Sulfate Ophthalmic Solution
Gentamicin Sulfate and Betamethasone Valerate Topical Solution
Gentamicin Sulfate and Betamethasone Acetate Ophthalmic Solution
Gentamicin Sulfate and Betamethasone Valerate Otic Solution
Gentamicin and Prednisolone Acetate Ophthalmic Ointment

Biochem/physiol Actions

作用机制：庆大大霉素通过和30S核糖亚基结合，引起密码子误读，阻碍肽酰转移酶从供体位点转移到受体位点。庆大霉素通过它与外膜的结合来发挥它对铜绿假单胞菌的杀菌作用，它在外膜上置换天然阳离子，使膜不稳定，并在细胞表面形成孔。

抗菌谱：包括革兰氏阴性和革兰氏阳性细菌，包括对于四环素、氯霉素、卡那霉素和粘菌素，某些特定假单胞菌菌株，变形杆菌属，Staphylococcus 和 Streptococcus 的抗性。

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.

Other Notes

This product is part of the USP Biologics program.

Legal Information

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Disclaimer

Sterile solutions should be stored at 2-8°C. Solutions have also been shown to be stable at room temperature and in boiling aqueous buffers of pH 2-14².

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pictograms

GHS07

signalword

Warning

hcodes

H317

pcodes

P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364

Hazard Classifications

Skin Sens. 1

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c