CN
- A biopharmaceutical plant on a chip: continuous micro-devices for the production of monoclonal antibodies.
A biopharmaceutical plant on a chip: continuous micro-devices for the production of monoclonal antibodies.
Lab on a chip (2013-02-16)
Lucía D Garza-García, Leydi M Carrillo-Cocom, Diana Araiz-Hernández, Pedro Soto-Vázquez, Julián López-Meza, Eduardo J Tapia-Mejía, Sergio Camacho-León, Erika García-López, Ciro A Rodríguez-González, Mario M Alvarez
PMID23412111
摘要
We report a proof-of-principle for the use of micro-devices as continuous bioreactors for the production of monoclonal antibodies. We culture CHO cells on the surface of PMMA "zigzag" channels textured with semi-spherical cavities coated with fibronectin, observing steady-state productivities 100 times higher than those observed in full scale systems.
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Supelco
聚甲基丙烯酸甲酯, analytical standard, for GPC, average Mw 97,000 (Typical), average Mn 46,000 (Typical)