神经免疫与神经炎症的免疫检测
免疫检测产品在神经免疫和神经炎症研究中的作用
神经炎症在创伤性脑损伤(TBI)和脊柱损伤所致神经退行性疾病的慢性发展中起着关键作用。这种炎症与阿尔茨海默症(AD)、帕金森病、肌萎缩性侧索硬化(ALS)和多发性硬化(MS)的疾病进展有关。在老年大脑中，促炎标志物的上升会增加认知障碍和神经退行性疾病发展风险。
我们现提供MILLIPLEX®多重检测试剂盒（适合Luminex®仪器平台）和单分子计数(SMC®)超灵敏检测试剂盒（适合SMCxPRO®仪器平台）来满足神经科学研究需要。有了这些免疫检测工具，科研人员就能监测神经退行性疾病发病前、慢性发展、病情减缓治疗中的生物标志物，进行神经免疫和神经炎症研究。
图 1.MILLIPLEX®人 Panel A试剂盒检测神经退行性疾病样本中的分析物浓度。比较了来自健康对照人群(n=9)、轻度认知障碍(MCI)患者(n=10)和AD患者(n=13)的CSF样本。**p < 0.005 ***p > 0.0005。
神经退行性疾病细胞因子的并行分析
研究人员可通过定量分析脑脊液(CSF)、血清/血浆、细胞培养物和组织裂解物样本中的神经炎症细胞因子和趋化因子标志物及神经退行性疾病生物标志物，进行神经炎症和神经退行性疾病相关进展研究。神经炎症可在AD等神经退行性疾病中起作用，因此广泛分析CSF样本中的细胞因子具有重要意义。MILLIPLEX®人细胞因子/趋化因子/生长因子免疫检测试剂盒（Panel A和Panel B）实现多种类型的多重生物分析，相比传统方法节省更多地时间、劳力和成本。
图 2.使用CSF样本检测AD生物标志物。通过SMC®试剂盒(SMC® Phospho-Tau (T181) Kit, SMC® Total Tau Kit, SMC® TDP-43 Kit, SMC® SNAP-25 Kit)分析对照人群和AD患者的CSF样本，表明磷酸化Tau T181(p<0.02)、总Tau蛋白(p<0.03)、TDP-43 (p<0.01)和SNAP-25(p<0.02)具有显著统计学差异。
神经退行性疾病生物标志物的超灵敏分析
对基于血液的AD生物标志物的需求推动了对新型候选物的不断寻找。然而，血液来源生物标志物的发现可能受标准免疫测定灵敏度限制。高灵敏度的免疫测定技术，例如SMC®技术，可在各种生物液体中检测低丰度蛋白，为新型生物标记物的发现创造机会，彻底革新神经退行性疾病研究。
索取神经炎症免疫检测产品相关信息
相关SMC®超灵敏检测试剂盒
仅供研究使用，不可用于诊断。
相关MILLIPLEX®多重检测试剂盒
仅供研究使用，不可用于诊断。
相关ELISA试剂盒
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