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MAB3484

Sigma-Aldrich

Anti-Cystic Fibrosis Transmembrane Conductance Regulator Antibody, a.a. 386-412, clone L12B4

clone L12B4, Chemicon®, from mouse

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别名:
CFTR
eCl@ss:
32160702
NACRES:
NA.41

生物来源

mouse

质量水平

100

抗体形式

purified immunoglobulin

抗体产品类型

primary antibodies

克隆

L12B4, monoclonal

种属反应性

human

请勿与下列物质发生反应

shark, mouse

制造商/商品名称

Chemicon®

技术

immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: suitable

同位素/亚型

IgG2a

NCBI登记号

NM_000492.3

UniProt登记号

P13569

运输

wet ice

基因信息

human ... CFTR(1080)

特异性

Human cystic fibrosis transmembrane conductance regulator (CFTR). Recognizes an epitope at the cytoplasmic region preceding the first nucleotide binding domain between residues 386 to 412.

Recognizes CFTR, Mr 170kDa and two additional proteins at ~ Mr 100 and 140kDa.

免疫原

Epitope: a.a. 386-412 of human CFTR

应用

Anti-Cystic Fibrosis Transmembrane Conductance Regulator Antibody, a.a. 386-412, clone L12B4 is an antibody against Cystic Fibrosis Transmembrane Conductance Regulator for use in IC, IP & WB.
Research Category
Neuroscience
Research Sub Category
Ion Channels & Transporters
Western blot: 1-10μg/mL, note do not boil the lysate, incubate at 80C for 30 minutes prior to running SDS-PAGE. CTFR aggregates upon boiling. Antibody recognizes CFTR at 170kDa and two additional proteins at 100 & 140kDa.

Immunoprecipitation

Immunofluorescence

Note: Does not work on paraffin embedded tissue.

Optimal working dilutions must be determined by the end user.

外形

Format: Purified
Purified immunoglobulin. Liquid in 0.02 M Phosphate buffer, 0.25 M NaCl, pH 7.6 with 0.1% sodium azide.

储存及稳定性

Maintain at 2-8°C in undiluted aliquots up to 6 months.

其他说明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律信息

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

储存分类代码

10 - Combustible liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

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Lacking CD56 expression in a relapsing cutaneous blastic plasmacytoid dendritic cell neoplasm after allogeneic bone marrow transplantation: FISH analysis revealed loss of 11q.
Mitteldorf C, Bertsch HP, Baumgart M, Haase D, Wulf G, Schon MP, Rosenwald A, Neumann C, Kaune KM.
Journal of the European Academy of Dermatology and Venereology : JEADV null
Targeted quantitation of overexpressed and endogenous cystic fibrosis transmembrane conductance regulator using multiple reaction monitoring tandem mass spectrometry and oxygen stable isotope dilution.
Jiang H, Ramos AA, Yao X
Analytical Chemistry null
Mauricio Di Fulvio et al.
PloS one, 15(12), e0242749-e0242749 (2020-12-03)
Cystic fibrosis (CF) is due to mutations in the CF-transmembrane conductance regulator (CFTR) and CF-related diabetes (CFRD) is its most common co-morbidity, affecting ~50% of all CF patients, significantly influencing pulmonary function and longevity. Yet, the complex pathogenesis of CFRD
Ana Isabel Mendes et al.
Molecular and cellular biology, 31(19), 4076-4086 (2011-08-03)
Members of the WNK (with-no-lysine [K]) subfamily of protein kinases regulate various ion channels involved in sodium, potassium, and chloride homeostasis by either inducing their phosphorylation or regulating the number of channel proteins expressed at the cell surface. Here, we
CFTR localization in native airway cells and cell lines expressing wild-type or F508del-CFTR by a panel of different antibodies
Carvalho-Oliveira, Isabel, et al
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 52, 193-203 (2004)
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