159549
4-(Bromomethyl)benzoic acid
97%
Synonym(s):
α-Bromo-p-toluic acid
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About This Item
Linear Formula:
BrCH2C6H4CO2H
CAS Number:
Molecular Weight:
215.04
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
EC Number:
228-343-3
Beilstein/REAXYS Number:
1862870
MDL number:
Assay:
97%
Form:
solid
Quality Level
assay
97%
form
solid
mp
224-229 °C (lit.)
functional group
bromo, carboxylic acid
SMILES string
OC(=O)c1ccc(CBr)cc1
InChI
1S/C8H7BrO2/c9-5-6-1-3-7(4-2-6)8(10)11/h1-4H,5H2,(H,10,11)
InChI key
CQQSQBRPAJSTFB-UHFFFAOYSA-N
Application
4-(Bromomethyl)benzoic acid was used in the chemical modification of 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (temoporfin), second generation photosensitizer. It was also used in the synthesis of 4-(5-arylidene-2,4-dioxothiazolidin-3-yl) methylbenzoic acids.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Q Yu et al.
Chemical communications (Cambridge, England), 50(81), 12150-12153 (2014-09-02)
LiYF4:Tm(3+)/Yb(3+) upconverting nanoparticles (UCNPs) were functionalized with the second generation photosensitizer 5,10,15,20-tetra(m-hydroxyphenyl)chlorin (m-THPC, Temoporfin, Foscan®). m-THPC was modified using 4-(bromomethyl)benzoic acid, which induced a bathochromic shift of the m-THPC blue absorption peak. The nanoconstruct causes up to 70% cell death
Rosanna Maccari et al.
Bioorganic & medicinal chemistry, 15(15), 5137-5149 (2007-06-05)
4-(5-Arylidene-2,4-dioxothiazolidin-3-yl)methylbenzoic acids (2) were synthesized and evaluated in vitro as inhibitors of PTP1B and LMW-PTP, two protein tyrosine phosphatases (PTPs) which act as negative regulators of the metabolic and mitotic signalling of insulin. The synthesis of compounds 2 represents an
Marcela S Lopes et al.
European journal of medicinal chemistry, 46(11), 5443-5447 (2011-09-24)
A series of nitroaromatic compounds was synthesized and evaluated as potential antileishmanial and trypanocidal agents. Five compounds exerted significant anti-leishmanial activity in vitro against promastigotes forms of Leishmania (L.) amazonensis, with IC(50) in the range of 23-59 μmol L(-1), but
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 159549-5G | 04061838744654 |
| 159549-10G | 04061838744647 |
| 159549-50G | 04061832489285 |