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254886

6,7-Dimethoxycoumarin

Name: 6,7-Dimethoxycoumarin
Brand: ALDRICH

98%

Synonym(s):

6,7-Dimethylesculetin, O-Methylisoscopoletin, O-Methylscopoletin, Aesculetin dimethyl ether, Escoparone, Esculetin 6,7-dimethyl ether, Scoparone, Scopoletin methyl ether

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About This Item

Empirical Formula (Hill Notation):

C₁₁H₁₀O₄

CAS Number:

120-08-1

Molecular Weight:

206.19

NACRES:

NA.22

PubChem Substance ID:

24855271

UNSPSC Code:

12352100

EC Number:

204-369-0

MDL number:

MFCD00006871

Assay:

98%

Form:

powder

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Properties

Quality Level

200

assay

98%

form

powder

mp

143-145 °C (lit.)

functional group

ester

SMILES string

COc1cc2OC(=O)C=Cc2cc1OC

InChI

1S/C11H10O4/c1-13-9-5-7-3-4-11(12)15-8(7)6-10(9)14-2/h3-6H,1-2H3

InChI key

GUAFOGOEJLSQBT-UHFFFAOYSA-N

Gene Information

mouse ... Maoa(17161)
rat ... Aldh1a2(116676)

Description

General description

6,7-Dimethoxycoumarin inhibits the in vitro growth of Phytophthora citrophthora, Verticillium dahliae, Penicillium digitatum, P. italicum, Colletotrichum gloeosporioides, Diplodia natalensis and Hendersonula toruloidea. Determination and pharmacokinetic study of 6,7-dimethoxycoumarin in rat plasma after intragastric administration of different decoctions of Yinchenhao Tang by reversed-phase HPLC method with UV detection has been reported.

pictograms

GHS06

signalword

Danger

hcodes

H301,H319

pcodes

P301 + P310 + P330 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Simultaneous in vivo RP-HPLC-DAD quantification of multiple-component and drug-drug interaction by pharmacokinetics, using 6,7-dimethylesculetin, geniposide and rhein as examples.

Aihua Zhang et al.

Biomedical chromatography : BMC, 26(7), 844-850 (2011-11-10)

Increasing evidence has demonstrated that multidrug combinations could amplify the therapeutic efficacies of each agent. Interestingly, the pharmacological effect of traditional Chinese medicine (TCM) is usually attributed to the drug-interaction property (synergism) of multiple active constituents. Pharmacokinetics is a useful

Separation of two constituents from purple sweet potato by combination of silica gel column and high-speed counter-current chromatography.

Kai He et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 881-882, 49-54 (2011-12-27)

It is known that the choice of solvent system for high speed counter-current chromatography separation is of utmost importance. In this study, a simple and rapid thin layer chromatograph coupling with fluorometric (TLC-F) method has been used to determine the

Chemical constituents from Lobelia chinensis and their anti-virus and anti-inflammatory bioactivities.

Ping-Chung Kuo et al.

Archives of pharmacal research, 34(5), 715-722 (2011-06-10)

In total, forty six compounds, including the novel compound lobechine (1), were characterized from the methanol extracts of Lobelia chinensis. The chemical structures of known metabolites were identified by comparing their spectroscopic and physical data with compounds reported in the

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Global Trade Item Number

SKU	GTIN
254886-250MG	04061825998930
254886-1G	04061826661871