Quality Level
Assay
≥96.5% (TLC)
96.5-103.5% (T)
97%
form
crystals
reaction suitability
reaction type: Coupling Reactions
greener alternative product characteristics
Less Hazardous Chemical Syntheses
Inherently Safer Chemistry for Accident Prevention
Learn more about the Principles of Green Chemistry.
application(s)
peptide synthesis
greener alternative category
, Aligned
storage temp.
2-8°C
SMILES string
F[P-](F)(F)(F)(F)F.CCOC(=O)C(=NO\C(N1CCOCC1)=[N+](/C)C)C#N
InChI
1S/C12H19N4O4.F6P/c1-4-19-11(17)10(9-13)14-20-12(15(2)3)16-5-7-18-8-6-16;1-7(2,3,4,5)6/h4-8H2,1-3H3;/q+1;-1/b14-10-;
InChI key
GPDHNZNLPKYHCN-DZOOLQPHSA-N
General description
Application
Advantages
- Equal or even superior performance to HATU
- Non-explosive (does not contain benzotriazole moiety)
- Suitable for solution phase & solid phase peptide synthesis
- Utmost retention of configuration – low to non-existent racemization
- High solubility and stability in typical solvents
- Visual or colorimetric reaction monitoring possible
- Easy removal of water-soluble by-products
Legal Information
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
Certificates of Analysis (COA)
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Articles
COMU is a non-explosive coupling agent suitable for solution phase & solid phase peptide synthesis. Its activity meets or exceeds that of HATU and its water-soluble by-product are easily removed.
Protocols
Amide Coupling in a Box
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