910074
27,27-Dimethyl-25-oxo-3,6,9,12,15,18,26-heptaoxaoctacosanoic acid
≥95%
Synonym(s):
2-2-2-2-2-2-6 PROTAC® linker, Bifunctional linker, OtBu-PEG6-acid
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About This Item
Empirical Formula (Hill Notation):
C23H44O10
Molecular Weight:
480.59
UNSPSC Code:
12352106
Assay:
≥95%
Form:
liquid
assay
≥95%
form
liquid
reaction suitability
reagent type: linker
functional group
carboxylic acid, ester
storage temp.
2-8°C
SMILES string
O=C(CCCCCCOCCOCCOCCOCCOCCOCC(O)=O)OC(C)(C)C
Application
This heterobifunctional, PEGylated crosslinker 27,27-dimethyl-25-oxo-3,6,9,12,15,18,26-heptaoxaoctacosanoic acid features a carboxyl group at one end and a t-butyl protected carboxylic acid at the other and exhibits both hydrophobic and hydrophilic moieties for use in biological applications. The linker can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or pproteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation where the linker region is referred to as 2-2-2-2-2-2-6.
Other Notes
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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