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920436

Sigma-Aldrich

NanoFabTx™ PEG-PLA drug formulation screening kit

for synthesis of PEGylated nanoparticles

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Synonym(s):
Microfluidics, NanoFabTx™ reagent kit, Nanoformulation, Nanoparticle kit, PEG-PLA

description

Kit components :
PEGPLA-L-M (919942-500mg)
PEGPLA-H-M (919934-500mg)
Stabilizer-Nano (907766-5g)
PEG-PLA drug formulation screening kit, for synthesis of PEGylated PLA nanoparticles

Quality Level

100

application(s)

advanced drug delivery

storage temp.

2-8°C

Related Categories

General description

NanoFabTx™ PEG-PLA drug formulation screening kit is a nanoformulation kit containing rationally selected PEGylated PLA polymers that have been used widely for controlled drug release of many different types of therapeutic molecules. The kit contains protocols for two different particle synthesis methods:
  • A Nanoprecipitation protocol to prepare drug-encapsulated nanoparticles in standard laboratory glassware.
  • A Microfluidics protocol using commercial platforms or syringe pumps.
The microfluidics protocol uses NanoFabTx™ device kits (911593), which provide all the microfluidics chips, fittings, and tubing required to get started with microfluidics-based synthesis (compatible microfluidics system or syringe pump required).

Application

NanoFabTx™ PEG-PLA drug formulation screening kit enables users to encapsulate a wide variety of therapeutic drug molecules in specifically sized, biodegradable, PEGylated PLA nanoparticles. By simplifying the chemistry and providing an easy-to-use toolkit with step-by-step instructions, our NanoFabTx™ nanoformulation screening kit helps researchers achieve reproducible synthesis of drug encapsulating nanoparticles with narrow size dispersity, eliminating the need for lengthy trial-and-error optimization. Suitable for biomedical research applications such as oncology, immuno-oncology, gene delivery, and vaccine delivery, PEG-PLA nanoparticles, made using the NanoFabTx™ PEG-PLA drug formulation screening kit, are designed for maximizing the encapsulation of hydrophobic drugs to minimize the time and expensive wasted reagents of synthetic optimization.

Features and Benefits

  • Includes tested protocols with step-by-step instructions for nanoprecipitation or microfluidics-based syntheses
  • Requires minimal laboratory setup
  • Optimized to achieve monodisperse, homogenously shaped, biodegradable, PEGylated PLA nanoparticles in any size between 60 and 100 nm
  • Formulated to maximize the encapsulation of hydrophobic drugs
  • Includes two different PEGylated PLAs

Legal Information

NANOFABTX is a trademark of Sigma-Aldrich Co. LLC

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Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Regulatory Information

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Solène Passemard et al.
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The production of hydrogel microspheres (MS) for cell immobilization, maintaining the favorable properties of alginate gels but presenting enhanced performance in terms of in vivo durability and physical properties, is desirable to extend the therapeutic potential of cell transplantation. A
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Theranostic nanomedicine has recently emerged as an appealing approach for tumor chemotherapy. Here, for the first time, fluorescent carbon dots (Cdots) were used as cross-linker for tumor theranostic nanoparticles. Novel theranostic nanoparticles of approximately 27 nm with a doxorubicin (DOX)
Redouan Mahou et al.
Materials (Basel, Switzerland), 7(1), 275-286 (2014-01-09)
The progress of medical therapies, which rely on the transplantation of microencapsulated living cells, depends on the quality of the encapsulating material. Such material has to be biocompatible, and the microencapsulation process must be simple and not harm the cells.
Verónica Lassalle et al.
Macromolecular bioscience, 7(6), 767-783 (2007-06-02)
The controlled release of medicaments remains the most convenient way of drug delivery. Therefore, a wide variety of reports can be found in the open literature dealing with drug delivery systems. In particular, the use of nano- and microparticles devices
Nazila Kamaly et al.
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