922307
Poly(lactide-alt-glycolide)
average Mn 10000, lactide:glycolide 50:50
Synonym(s):
PLLA-alt-PGA
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About This Item
Linear Formula:
(C5H6O4)n
NACRES:
NA.23
UNSPSC Code:
12162002
form
powder
Quality Level
feed ratio
lactide:glycolide 50:50
mol wt
average Mn 10000
color
white to beige
storage temp.
2-8°C
Application
Poly(lactide-alt-glycolide) contains alternating sequence of lactide and clycolide in the polymer chain, unlike Poly(lactide-co-glycolide) (PLGA). The molar ratio of lactic to glycolic units in the polymer is exactly 1:1. Poly(lactide-alt-glycolide) has improved solutibilty in a broad range of organic solvents such as acetonitrile, acetone, dioxane, DCM and THF, providing great convenience for drug delivery researches and applications. Traditional PLGA polymers have a random distribution of glycolide and lactide units which impacts solutibilty. Compared to random PLGA with LA:GA ratios of 50/50, alternative PLGA undergoes hydrolysis in vivo with minimal changes in pH and a lower amount of acidic by-products.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Lin Yu et al.
Biomacromolecules, 12(4), 1290-1297 (2011-03-03)
This paper reports the influence of sequence structures of block copolymers composed of poly(lactic acid-co-glycolic acid) (PLGA) and poly(ethylene glycol) (PEG) on their thermogelling aqueous behaviors. A series of thermogelling PLGA-PEG-PLGA triblock copolymers with similar chemical compositions and block lengths
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 922307-1G | 04065266714906 |