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H57807

4-Hydroxyquinazoline

Name: 4-Hydroxyquinazoline
Brand: ALDRICH

98%

Synonym(s):

4-Quinazolinol

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About This Item

Empirical Formula (Hill Notation):

C₈H₆N₂O

CAS Number:

491-36-1

Molecular Weight:

146.15

NACRES:

NA.22

PubChem Substance ID:

24895709

UNSPSC Code:

12352100

EC Number:

207-735-8

MDL number:

MFCD00511302

Assay:

98%

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Properties

Quality Level

100

assay

98%

mp

216-219 °C (lit.)

SMILES string

O=C1NC=Nc2ccccc12

InChI

1S/C8H6N2O/c11-8-6-3-1-2-4-7(6)9-5-10-8/h1-5H,(H,9,10,11)

InChI key

QMNUDYFKZYBWQX-UHFFFAOYSA-N

Gene Information

mouse ... Parp2(11546)

Description

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Loss of the MYC gene amplified in human HL-60 cells after treatment with inhibitors of poly(ADP-ribose) polymerase or with dimethyl sulfoxide.

H Shima et al.

Proceedings of the National Academy of Sciences of the United States of America, 86(19), 7442-7445 (1989-10-01)

In HL-60 cells, a human promyelocytic leukemia cell line, the human c-myc gene, designated MYC, is amplified about 16-fold. On differentiation of the HL-60 cells into granulocytes induced by several inhibitors of poly(ADP-ribose) polymerase [NAD+ poly(adenosine diphosphate D-ribose)ADP-D-ribosyltransferase, EC 2.4.2.30]

DFT studies of the structure and vibrational assignments of 4-hydroxy quinazoline and 2-hydroxy benzimidazole.

V Krishnakumar et al.

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 66(4-5), 1082-1090 (2006-07-28)

The solid phase FT-IR and FT-Raman spectra of 4-hydroxy quinazoline and 2-hydroxy benzimidazole have been recorded in the regions 4000-400 and 3500-100 cm-1, respectively. Theoretical information on the optimised geometry, harmonic vibrational frequencies, infrared and Raman intensities were obtained by

Topoisomerase inhibitors induce apoptosis in thymocytes.

Y Onishi et al.

Biochimica et biophysica acta, 1175(2), 147-154 (1993-01-17)

The effects of the inhibitors of topoisomerase I and II, camptothecin and etoposide, as well as novobiocin and adriamycin, on the DNA fragmentation and viability of mouse thymocytes in primary culture were examined. All inhibitors were shown to produce dose-dependent

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Global Trade Item Number

SKU	GTIN
H57807-5G	04061833799765