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P14815

4-Ethoxyaniline

Name: 4-Ethoxyaniline
Brand: ALDRICH

98%

Synonym(s):

p-Phenetidine, 4-Ethoxyaniline

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About This Item

Linear Formula:

C₂H₅OC₆H₄NH₂

CAS Number:

156-43-4

Molecular Weight:

137.18

UNSPSC Code:

12352100

NACRES:

NA.22

PubChem Substance ID:

24898204

EC Number:

205-855-5

Beilstein/REAXYS Number:

606666

MDL number:

MFCD00007865

Assay:

98%

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Properties

Quality Level

200

assay

98%

refractive index

n20/D 1.559 (lit.)

bp

250 °C (lit.)

mp

2-5 °C (lit.)

density

1.065 g/mL at 25 °C (lit.)

SMILES string

CCOc1ccc(N)cc1

InChI

1S/C8H11NO/c1-2-10-8-5-3-7(9)4-6-8/h3-6H,2,9H2,1H3

InChI key

IMPPGHMHELILKG-UHFFFAOYSA-N

Description

pictograms

GHS08,GHS07

signalword

Warning

hcodes

H302 + H312 + H332,H317,H319,H341

pcodes

P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Muta. 2 - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

251.6 °F - closed cup

flash_point_c

122 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Regulatory Information

危险化学品

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Cellular effects of N(4-ethoxyphenyl)p-benzoquinone imine, a p-phenetidine metabolite formed during peroxidase reactions.

R Larsson et al.

Chemico-biological interactions, 60(3), 317-330 (1986-12-01)

The interaction of N-(4-ethoxyphenyl)p-benzoquinone imine (NEPBQI), a metabolite formed during peroxidase catalyzed metabolism of p-phenetidine, with GSH and its effects in isolated rat hepatocytes were investigated. When reacted with GSH NEPBQI formed both a mono- and a diglutathione conjugate as

Prostaglandin synthase catalyzed metabolic activation of p-phenetidine and acetaminophen by microsomes isolated from rabbit and human kidney.

R Larsson et al.

The Journal of pharmacology and experimental therapeutics, 235(2), 475-480 (1985-11-01)

The metabolism of p-phenetidine in microsomes from rabbit kidney and the metabolism of acetaminophen and p-phenetidine in human kidney microsomes to protein binding metabolites were examined. Microsomal preparations from rabbit kidney medulla catalyzed the irreversible arachidonic acid-dependent binding of p-[14C]phenetidine

Metabolic activation of phenacetin and phenetidine by several forms of cytochrome P-450 purified from liver microsomes of rats and hamsters.

T Nohmi et al.

Japanese journal of cancer research : Gann, 78(2), 153-161 (1987-02-01)

Metabolic activation of phenacetin by liver microsomes proceeds via both phenetidine and N-hydroxyphenacetin to direct-acting mutagens, i.e., N-hydroxyphenetidine and p-nitrosophenetole. Five different molecular species of cytochrome P-450 have been purified from liver microsomes of drug-pretreated Wistar rats or Syrian hamsters

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Global Trade Item Number

SKU	GTIN
P14815-100G	04061834355083
P14815-500G	04061838355362