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About This Item
Empirical Formula (Hill Notation):
C39H68N5O11P
CAS Number:
Molecular Weight:
813.96
MDL number:
NACRES:
NA.25
UNSPSC Code:
12352211
Product Name
18:1-12:0 NBD PA, Avanti Research™ - A Croda Brand 810176C
assay
>99% (TLC)
form
liquid
packaging
pkg of 1 × 1 mL (810176C-1mg)
manufacturer/tradename
Avanti Research™ - A Croda Brand 810176C
concentration
1 mg/mL (810176C-1mg)
shipped in
dry ice
storage temp.
−20°C
General description
Phosphatidic acid (PA) is a simple anionic membrane phospholipid. The amphipathic phospholipid contains a polar head group and two long hydrophobic acyl chains. NBD PA is a fluorescent probe containing 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) linked to the sn-2 fatty acid of PA.
Application
18:1-12:0 NBD PA or 1-oleoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphate (ammonium salt) has been used in donor liposomes for phosphatidic acid (PA) transfer activity assay. It might be used:in the preparation of PA small unilamellar vesicles (SUVs) to determine mammalian target of rapamycin complex 1 (mTORC1) lysosomal translocation. It may be used in NBD-PA and NBD phosphatidyl choline uptake assays and to measure lipid transfer specificity of Ups1 mutants
Biochem/physiol Actions
Phosphatidic acid (PA) is crucial for intracellular signaling involved in various cellular processes, including membrane trafficking and sperm hyper-activation. PA reacts with water and other phospholipids to produce lipid bilayers and multicomponent bilayers, respectively.
Packaging
5 mL Amber Glass Screw Cap Vial (810176C-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC
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signalword
Danger
target_organs
Central nervous system, Liver,Kidney
wgk
WGK 3
Storage Class
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
flash_point_f
does not flash
flash_point_c
does not flash
Hazard Classifications
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 3
Regulatory Information
易制毒化学品（2类）
危险化学品
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Phosphatidic acid drives mTORC1 lysosomal translocation in the absence of amino acids
Frias MA, et al.
Test null
Bioactive Lipids
An Introduction to Biological Membranes, 453-478 (2016)
Molecular mechanism of mitochondrial phosphatidate transfer by Ups1
Lu J, et al.
Communications biology null
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 810176C-1MG | 04061837666667 |