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04-145

Anti-NOD2 Antibody, clone 2D9

Name: Anti-NOD2 Antibody, clone 2D9
Brand: MM

clone 2D9, from mouse

Synonym(s):

Caspase recruitment domain-containing protein 15, Inflammatory bowel disease protein 1, NLR family, CARD domain containing 2, NOD-like receptor C2, caspase recruitment domain family, member 15, caspase recruitment domain protein 15, nucleotide-binding ol

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

eCl@ss:

32160702

Conjugate:

unconjugated

Clone:

2D9, monoclonal

Application:

IHC, IP, WB

Citations:

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Properties

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

2D9, monoclonal

species reactivity

human

technique(s)

immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable

isotype

IgG1κ

NCBI accession no.

NP_071445

UniProt accession no.

Q9HC29

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... NOD2(64127)

Description

General description

NOD2 (nucleotide-binding oligomerization domain containing 2), also known as the caspase recruitment domain family, member 15 (CARD15), is a member of the NOD-like Receptor (NLR) family of proteins and plays an important role in the immune system. It is an intracellular pattern recognition receptor and is linked to inflammatory diseases such as inflammatory bowel disease/Crohn′s Disease and Blau syndrome. NOD2 has two caspase recruitment domains (CARDs) and eleven leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response by recognizing the bacterial molecules. Recently it is has been found to interact with NLRC4 and bind to MAVS in response to ssRNA or viral RNA treatment and activate the IFN response.

~110 kDa

Immunogen

Epitope: Unknown

His-tagged recombinant protein corresponding to human NOD2.

Application

Anti-NOD2 Antibody, clone 2D9 is a Mouse Monoclonal Antibody for detection of NOD2 also known as NOD-like receptor C2 & has been validated in IHC, WB & IP.

Research Category
Inflammation & Immunology

Research Sub Category
Immunological Signaling

Biochem/physiol Actions

This antibody recognizes NOD2.

Physical form

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Control
Hyperplastic colorectal carcinoma tissue

Immunohistochemistry Analysis: A 1:25 dilution of this antibody detected NOD2 in hyperplastic colorectal carcinoma tissue.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c