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1.00002

Tri-n-butyl phosphate

EMPROVE® EXPERT, Ph. Eur.

Synonym(s):

Tributyl phosphate, TBP, TBPA

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About This Item

Linear Formula:
(CH3(CH2)3O)3PO
CAS Number:
126-73-8
Molecular Weight:
266.31
EC Index Number:
204-800-2
UNSPSC Code:
12352303
Beilstein/REAXYS Number:
1710584
MDL number:
MFCD00009436
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agency

Ph. Eur.

Quality Level

500

vapor density

9.2 (vs air)

vapor pressure

27 mmHg ( 178 °C), 7.3 mmHg ( 150 °C)

product line

EMPROVE® EXPERT

form

liquid

autoignition temp.

770 °F

bp

180-183 °C/22 mmHg (lit.)

mp

−79 °C (lit.)

transition temp

flash point 146 °C

solubility

6 g/L

density

0.979 g/mL at 25 °C (lit.)

application(s)

liquid formulation
pharma/biopharma processes
pharmaceutical

storage temp.

15-25°C

SMILES string

CCCCOP(=O)(OCCCC)OCCCC

InChI

1S/C12H27O4P/c1-4-7-10-14-17(13,15-11-8-5-2)16-12-9-6-3/h4-12H2,1-3H3

InChI key

STCOOQWBFONSKY-UHFFFAOYSA-N

General description

Chemicals play an important role in the stabilization of a biologic drug during its manufacturing and formulation process – for instance, by preventing aggregation. We offer a wide range of high-quality stabilizers, buffers and salts to successfully purify and formulate your biomolecules. Specifically developed for high-risk applications, they are low in bioburden and endotoxins.
As part of our Emprove® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Tri-n-butyl phosphate is used widely as a solvent along with either TritonTM X100 or Tween® in solvent detergent treatment for viral inactivation procedures especially for plasma derived therapeutics.
Due to its low microbial and endotoxin limits, Tri-n-butyl phosphate Emprove® Expert is especially suitable for high-risk applications.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany
TWEEN is a registered trademark of Croda International PLC

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pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Skin Irrit. 2

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

293.0 °F - closed cup

flash_point_c

145 °C - closed cup

Certificates of Analysis (COA)

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Global Trade Item Number

SKUGTIN
100002050004027269080457
100002250004027269080464
100002902604027269080471