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216100-M

Carboplatin

An analog of Cisplatin with reduced nephrotoxicity. Displays potent antitumor activity.

Synonym(s):

Carboplatin, cis-Diamine[1,1-cyclobutanedicarboxylato]platinum(II), JM-8, Paraplatin

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About This Item

Empirical Formula (Hill Notation):
C6H12N2O4Pt
CAS Number:
41575-94-4
Molecular Weight:
371.25
UNSPSC Code:
12352200
MDL number:
MFCD00070464
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
solid
Quality level:
100
Storage condition:
OK to freeze
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Quality Level

100

description

Merck USA index - 14, 1822

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white

solubility

water with 5% glucose: 10 mg/mL

storage temp.

10-30°C

SMILES string

[Pt]1OC(=O)C2(CCC2)C(=O)O1.[N+H4].[N+H4]

InChI

1S/C6H8O4.2H3N.Pt/c7-4(8)6(5(9)10)2-1-3-6;;;/h1-3H2,(H,7,8)(H,9,10);2*1H3;/q;;;+2

InChI key

OLESAACUTLOWQZ-UHFFFAOYSA-N

General description

An analog of Cisplatin (Cat. No. 232120 ) with reduced nephrotoxicity. Displays potent antitumor activity.


Note: Athough soluble in DMSO, Carboplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Water with or without 5% glucose is recommended for solubilization prior to culture treatment.
An analog of cisplatin with reduced nephrotoxicity. Displays potent antitumor activity.



Note: Athough soluble in DMSO, Carboplatin is reported to be rendered inactive due to ligand displacement by the nucleophilic sulfur of DMSO. Water with or without 5% glucose is recommended for solubilization prior to culture treatment.

Biochem/physiol Actions

Primary Target
Potent antitumor activity

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Hall, M.D., et al. 2014. Cancer Res. In press.
Smith, I.E., et al. 1985. Cancer Treat. Rep. 69, 43.
Harland, S.J., et al. 1984. Cancer Res. 44, 1693.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

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pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Muta. 1B - Repr. 1B - Resp. Sens. 1 - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

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Global Trade Item Number

SKUGTIN
216100-25MG04055977219265