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219421

Cathepsin L Inhibitor I

Name: Cathepsin L Inhibitor I
Brand: MM

The Cathepsin L Inhibitor I, also referenced under CAS 108005-94-3, controls the biological activity of Cathepsin L. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Synonym(s):

Cathepsin L Inhibitor I, Z-FF-FMK

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About This Item

Empirical Formula (Hill Notation):

C₂₇H₂₇FN₂O₄

CAS Number:

108005-94-3

Molecular Weight:

462.51

MDL number:

MFCD24369030

UNSPSC Code:

12352200

NACRES:

NA.77

Form:

solid

Quality level:

100

Storage condition:

OK to freeze, desiccated

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Properties

Quality Level

100

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated

color

white

solubility

DMSO: 20 mM

shipped in

ambient

storage temp.

−20°C

SMILES string

FCC(=O)C(NC(=O)C(NC(=O)OCc3ccccc3)Cc2ccccc2)Cc1ccccc1

InChI

1S/C27H27FN2O4/c28-18-25(31)23(16-20-10-4-1-5-11-20)29-26(32)24(17-21-12-6-2-7-13-21)30-27(33)34-19-22-14-8-3-9-15-22/h1-15,23-24H,16-19H2,(H,29,32)(H,30,33)

InChI key

CAILNONEKASNSH-UHFFFAOYSA-N

Description

General description

A potent, cell-permeable and irreversible inhibitor of cathepsin L.

A potent, cell-permeable, and irreversible inhibitor of Cathepsin L (Cat. No. 219402 ).

Biochem/physiol Actions

Cell permeable: yes

Primary Target
cathepsin L

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Analysis Note

single spot by TLC

Other Notes

Ravanko, K., et al. 2004. Cancer Res.64, 8831.
Esser, R.E., et al. 1994. Arthritis Rheum. 37, 236.
Shaw, E., et al. 1993. FEBS Lett.334, 340.

Z-Phe-Phe-CH₂F

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Standard Handling (A)

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c