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8.18737

Chlorotrimethylsilane

for synthesis

Synonym(s):

Chlorotrimethylsilane, Trimethylchlorosilane, Trimethylsilyl chloride, TMCS

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About This Item

Linear Formula:
(CH3)3SiCl
CAS Number:
75-77-4
Molecular Weight:
108.64
UNSPSC Code:
12352103
EC Index Number:
200-900-5
NACRES:
NA.22
MDL number:
MFCD00000502
Assay:
≥99.0% (GC)
Form:
liquid
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vapor pressure

250 hPa ( 20 °C)

Quality Level

200

assay

≥99.0% (GC)

form

liquid

autoignition temp.

420 °C

potency

4868 mg/kg LD50, oral (Rat), 1530 mg/kg LD50, skin (Rabbit)

expl. lim.

1.5-46 % (v/v)

bp

57 °C/1013 hPa

mp

-58 °C

transition temp

flash point -20 °C

density

0.86 g/cm3 at 20 °C

storage temp.

2-30°C

SMILES string

[Si](Cl)(C)(C)C

InChI

1S/C3H9ClSi/c1-5(2,3)4/h1-3H3

InChI key

IJOOHPMOJXWVHK-UHFFFAOYSA-N

Application

  • Synthesis of bis ferrocene derivatives: Development of new ferrocenyl multi-functional silyl ether compounds using chlorotrimethylsilane, highlighting advances in organosilicon chemistry (R Teimuri-Mofrad et al., 2016).
  • Pharmacologically active derivatives: Use of chlorotrimethylsilane as a catalyst in the synthesis of pharmacologically active bis (indolyl) and tris (indolyl) derivatives, demonstrating its efficiency in electrophilic substitution reactions (NG Singh et al., 2014).
  • Silicone resin synthesis: Exploration of the hydrolysis-condensation reaction of tetraethoxysilane and chlorotrimethylsilane to create silicone resins, showing the material′s enhanced properties for industrial applications (CFJ Kuo et al., 2014).
  • Deoxygenation of unsymmetrical dicarbonyl compounds: Innovative use of chlorotrimethylsilane and sodium iodide for the selective reduction of 1,2-diketones, showcasing a novel method in organic synthesis (LZ Yuan et al., 2016).
  • Enhanced activity and durability of catalysts: Investigation into Fe3+ and chlorotrimethylsilane modified NaY catalysts for the acetalization of glycerol to solketal, improving catalytic performance in chemical processes (Y Li et al., 2023).

Analysis Note

Assay (GC, area%): ≥ 99.0 % (a/a)
Density (d 20 °C/ 4 °C): 0.858 - 0.861
Identity (IR): passes test

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Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1A

supp_hazards

EUH014

Storage Class

3 - Flammable liquids

wgk

WGK 1

flash_point_f

-18.4 °F - closed cup

flash_point_c

-28 °C - closed cup

Regulatory Information

危险化学品

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Global Trade Item Number

SKUGTIN
818737010004022536444352
818737902304027269984540
818737050004022536444369