MAB1645
Anti-Dystrophin Antibody
CHEMICON®, mouse monoclonal, 1808
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Clone:
1808, monoclonal
Species reactivity:
chicken, mouse, rat, human
Application:
IHC, WB
Citations:
11
Product Name
Anti-Dystrophin Antibody, clone 1808, clone 1808, Chemicon®, from mouse
biological source
mouse
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
1808, monoclonal
species reactivity
chicken, mouse, rat, human
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry: suitable, western blot: suitable
isotype
IgG1
NCBI accession no.
UniProt accession no.
shipped in
dry ice
target post-translational modification
unmodified
Gene Information
human ... DMD(1756)
Immunogen
Peripheral membrane proteins extracted from Torpedo postsynaptic membranes.
Application
Anti-Dystrophin Antibody, clone 1808 detects level of Dystrophin & has been published & validated for use in WB, IH.
Western blot
Immunohistochemistry
Optimal working dilutions must be determined by the end user.
Immunohistochemistry
Optimal working dilutions must be determined by the end user.
Biochem/physiol Actions
By Western blot MAB1645 recognizes a single protein having a relative molecular weight of 300 kD. Reacts to mammalian skeletal muscle dystrophin. Shows no staining of mdx mouse muscle. Labels normal human muscle but not Duchenne muscle.
STAINING PATTERN:
On cryostat sections of normal mouse diaphragm MAB1645 gives strong immunofluorescence staining of the entire sarcolemma, with particularly strong staining of neuromuscular junctions.
SPECIES REACTIVITY:
Labels skeletal muscle from rat, chicken and Xenopus laevis. Labels cardiac muscle from rat and normal, but not mdx, mouse. Also labels smooth muscle from chicken gizzard.
STAINING PATTERN:
On cryostat sections of normal mouse diaphragm MAB1645 gives strong immunofluorescence staining of the entire sarcolemma, with particularly strong staining of neuromuscular junctions.
SPECIES REACTIVITY:
Labels skeletal muscle from rat, chicken and Xenopus laevis. Labels cardiac muscle from rat and normal, but not mdx, mouse. Also labels smooth muscle from chicken gizzard.
Physical form
Format: Purified
Liquid in 0.02 M phosphate buffer (pH 7.6), 250 mM NaCl with 0.1% sodium azide.
Preparation Note
Maintain at -20ºC for up to 12 months in convenient aliquots. Avoid repeated freeze/thaw cycles.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Storage Class
12 - Non Combustible Liquids
Certificates of Analysis (COA)
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Related Content
S H Gee et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 18(1), 128-137 (1998-01-24)
Syntrophins are cytoplasmic peripheral membrane proteins of the dystrophin-associated protein complex (DAPC). Three syntrophin isoforms, alpha1, beta1, and beta2, are encoded by distinct genes. Each contains two pleckstrin homology (PH) domains, a syntrophin-unique (SU) domain, and a PDZ domain. The
Andreas Schaefer et al.
Scientific reports, 9(1), 5710-5710 (2019-04-07)
Mechanical unloading (MU) by implantation of left ventricular assist devices (LVAD) has become clinical routine. This procedure has been shown to reverse cardiac pathological remodeling, with the underlying molecular mechanisms incompletely understood. Most studies thus far were performed in non-standardized
Dystrophin in a membrane skeletal network: localization and comparison to other proteins.
Dmytrenko, G M, et al.
The Journal of Neuroscience, 13, 547-558 (1993)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| MAB1645 | 04053252467950 |