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MAB1974

Anti-Integrin beta 3 (ITGB3/CD61) Antibody

CHEMICON®, mouse monoclonal, BB10

Synonym(s):

CD61

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Clone:
BB10, monoclonal
Species reactivity:
human
Application:
ICC, IHC, WB
Citations:
11
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Product Name

Anti-Integrin β3 Antibody, clone BB10, clone BB10, Chemicon®, from mouse

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

BB10, monoclonal

species reactivity

human

manufacturer/tradename

Chemicon®

technique(s)

immunocytochemistry: suitable, immunohistochemistry: suitable, western blot: suitable

isotype

IgG1

suitability

not suitable for immunohistochemistry (Paraffin)

NCBI accession no.

NM_000212.2

UniProt accession no.

P05106

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... ITGB3(3690)

Immunogen

Partially purified platelet glycoprotein IIb/lIIa complex.

Application

Anti-Integrin β3 Antibody, clone BB10 is an antibody against Integrin β3 for use in WB, IC, IH.
Immunoblotting: 1:1000 (Ylanne et al., 1988, 1990). The antibody is most effective when used against non-reduced samples.

immunohistochemistry (indirect immunofluorescence)1:200 - 1:400. (Ylanne et al., 1988).

Does not work on paraffin embedded sections.

Final working dilutions must be determined by end user.

Biochem/physiol Actions

Reacts with the beta-3 subunit of the integrin family, including GPIIIa of platelets. Recognized an extracellular epitope of beta-3.

Physical form

Format: Purified
Purified immunoglobulin. In PBS with 1% BSA and 0.1% sodium azide.

Preparation Note

Maintain between 2 and 8°C up to 12 months.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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External validation suggests Integrin beta 3 as prognostic biomarker in serous ovarian adenocarcinomas.
Partheen, K; Levan, K; Osterberg, L; Claesson, I; Sundfeldt, K; Horvath, G
BMC Cancer null
Localization of beta 1, beta 3, alpha 5, alpha v, and alpha IIb subunits of the integrin family in spreading human erythroleukemia cells.
Ylanne, J, et al.
Blood, 76, 570-577 (1990)
Karolina Partheen et al.
International journal of cancer, 123(9), 2130-2137 (2008-08-19)
The mortality rate for patients with ovarian carcinomas is high and the available prognostic factors are insufficient. The use of biomarkers may contribute to better prediction and survival for these patients. We aimed to study the gene and protein expressions
View All Related Papers

Global Trade Item Number

SKUGTIN
MAB197404053252265020