MABC282
Anti-BAG3 Antibody, clone AC-1
clone AC-1, from mouse
Synonym(s):
BAG family molecular chaperone regulator 3, BAG-3, Bcl-2-associated athanogene 3, Bcl-2-binding protein Bis, Docking protein CAIR-1
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About This Item
UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
AC-1, monoclonal
Application:
IHC, IP
Citations:
4
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
AC-1, monoclonal
species reactivity
human
technique(s)
immunohistochemistry: suitable (paraffin), immunoprecipitation (IP): suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... BAG3(9531)
General description
Bcl2-associated athanogene 3 (BAG3), also known as CAIR-1 or Bis, belongs to a family of six evolutionarily conserved co-chaperone proteins that contain a characteristic C-terminal BAG domain. In most cell types, BAG3 is localized to the cytoplasm, where it regulates the heat shock protein 70 chaperone. BAG3 is activated in response to stressful stimuli, and plays a critical role in modulating multiple cellular processes, including apoptosis, autophagy, embryonic development, and actin rearrangement. Abnormal expression of BAG3 results cardiomyopathy dilated type 1HH.
~62 kDa observed
Application
Detect BAG3 using this Anti-BAG3 Antibody, clone AC-1 validated for use in Immunoprecipitation, IHC(P).
Physical form
Format: Purified
Analysis Note
Evaluated by Immunoprecipitation in HeLa cell lysate.
Immunoprecipitation Analysis: 10 µg of this antibody immunoprecipitated BAG3 from HeLa cell lysate.
Immunoprecipitation Analysis: 10 µg of this antibody immunoprecipitated BAG3 from HeLa cell lysate.
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Storage Class
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
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Alessandra Rosati et al.
The American journal of pathology, 181(5), 1524-1529 (2012-09-05)
Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly cancers, being the fourth leading cause of cancer-related deaths. Long-term survival reaching 15% is achieved in less than 5% of patients who undergo surgery, and median survival is only 6
BAG3 controls angiogenesis through regulation of ERK phosphorylation.
Falco, A, et al.
Oncogene (2012)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| MABC282 | 04053252823688 |